Researchers discover blood biomarker for Lou Gehrig's disease, could lead to new treatments
Researchers from Brigham and Women's Hospital (BWH) are the first to discover that changes in monocytes (a type of white blood cell) are a biomarker for amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease. This finding ...
Medical research
Aug 06, 2012 |
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How immune system, inflammation may play role in Lou Gehrig's disease
In an early study, UCLA researchers found that the immune cells of patients with amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, may play a role in damaging the neurons in the spinal cord. ALS ...
Immunology
Jun 05, 2012 |
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Observations refute widely held view on causal mechanism in amyotrophic lateral sclerosis
In science, refuting a hypothesis can be as significant as proving one, all the more so in research aimed at elucidating how diseases proceed with a view toward preventing, treating, or curing them. Such a ...
Diseases, Conditions, Syndromes
Feb 29, 2012 |
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Proteins behaving badly: Researchers develop an algorithm to predict how and when proteins misfold
Several neurodegenerative diseases – including Alzheimer's and ALS (Lou Gehrig's disease) – are caused when the body's own proteins fold incorrectly, recruit and convert healthy proteins to the misfolded form, and ...
Medical research
Feb 23, 2012 |
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ALS researcher succumbs to disease he studied
(AP) -- Dr. Richard Olney, an internationally renowned researcher who dedicated his life to finding a cure for Lou Gehrig's disease, has died after his own eight-year battle with the disease. He was 64.
Medical research
Jan 31, 2012 |
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Disease progression halted in rat model of Lou Gehrig's disease
Amyotrophic lateral sclerosis (ALS; also known as Lou Gehrig's disease) is an incurable adult neurodegenerative disorder that progresses to paralysis and death. Genetic mutations are the cause of disease in 5% of patients ...
Medical research
Dec 12, 2011 |
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Genetic screening in yeast reveals new candidate gene for Lou Gehrig's disease
(Medical Xpress) -- Amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, is a universally fatal neurodegenerative disease. Mutations in two related proteins, TDP-43 and FUS, cause some forms of ALS. ...
Genetics
Nov 15, 2011 |
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Major breakthrough as researchers discover common cause of all forms of amyotrophic lateral sclerosis
The underlying disease process of amyotrophic lateral sclerosis (ALS and Lou Gehrig's disease), a fatal neurodegenerative disease that paralyzes its victims, has long eluded scientists and prevented development of effective ...
Diseases, Conditions, Syndromes
Aug 21, 2011 |
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Scientists solve mystery of nerve disease genes
For several years, scientists have been pondering a question about a genetic disease called Charcot-Marie-Tooth (CMT) disease type 2D: how can different types of mutations, spread out across a gene, produce ...
Medical research
Jul 04, 2011 |
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Failure in nerve-fiber navigation corrected in zebrafish model, suggests possibility of drug treatment
Spinal muscular atrophy (SMA) is the leading genetic cause of death in children under 2, with no treatment other than supportive care. In the Proceedings of the National Academy of Sciences, researchers at Children's Hospit ...
Medical research
Jun 06, 2011 |
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Mild obesity appears to improve survival in ALS patients
Patients with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, may be an exception to the rule that being overweight is a health hazard. In a retrospective study of over 400 ALS patients, Massachusetts ...
Diseases, Conditions, Syndromes
May 11, 2011 |
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Studies of mutated protein in Lou Gehrig's disease reveal new paths for drug discovery
Several genes have been linked to ALS, with one of the most recent called FUS. Two new studies in PLoS Biology, one from the University of Pennsylvania School of Medicine, and the other from colleagues at Bra ...
Genetics
Apr 26, 2011 |
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Researchers make strides in understanding amyotrophic lateral sclerosis
Brandeis researchers have made a significant advance in the effort to understand amyotrophic lateral sclerosis (ALS) by successfully reversing the toxicity of the mutated protein in the familial type of the ...
Medical research
Apr 26, 2011 |
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