Genetics
New method developed to target cause of Parkinson's
The discovery of a new way to target and treat the leading genetic contributor to Parkinson's may open the way for a potential new clinical treatment.
May 3, 2019
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News tagged with lysosomes
Medical research
Researchers solve mystery surrounding a form of Batten disease
A team led by researchers at Baylor College of Medicine has uncovered an unexpected mechanism that can explain a form of Batten disease called neuronal ceroid lipofuscinosis 8. The findings published in the journal Nature ...
Nov 5, 2018
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150
Alzheimer's disease & dementia
Alzheimer's linked to the brain's 'garbage disposal service'
Researchers in South Australia have found a genetic link between Alzheimer's disease and the endo-lysosomal system, a critical part of biological recycling machinery that maintains the health of brain cells.
Aug 21, 2018
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Oncology & Cancer
Study shows how to make (and destroy) a metastatic cancer cell
Many cancers become especially dangerous only when they metastasize from their site of origin to faraway tissues such as lung, brain or bone. Now, a University of Colorado Cancer Center study published today in the Proceedings ...
Aug 20, 2018
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140
Medical research
Simple sugar delays neurodegeneration caused by enzyme deficiency
A new therapeutic approach may one day delay neurodegeneration typical of a disease called mucopolysaccharidoses IIIB (MPS IIIB). Neurodegeneration in this condition results from the abnormal accumulation of essential cellular ...
Jun 20, 2018
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Genetics
Gene loss can lead to accumulation of waste products in cells
MIT biologists have discovered a function of a gene that is believed to account for up to 40 percent of all familial cases of amyotrophic lateral sclerosis (ALS). Studies of ALS patients have shown that an abnormally expanded ...
May 7, 2018
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Parkinson's & Movement disorders
Mechanism behind common Parkinson's mutation discovered
Northwestern Medicine investigators have discovered how a gene mutation results in buildup of a toxic compound known to cause Parkinson's disease symptoms, defining for the first time the mechanism underlying that aspect ...
Feb 5, 2018
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352
Parkinson's & Movement disorders
Genetic defects in the cell's 'waste disposal system' linked to Parkinson's disease
An international study has shed new light on the genetic factors associated with Parkinson's disease, pointing at a group of lysosomal storage disorder genes as potential major contributors to the onset and progression of ...
Nov 14, 2017
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Medical research
Study reveals key molecular link in major cell growth pathway
A team of scientists led by Whitehead Institute has uncovered a surprising molecular link that connects how cells regulate growth with how they sense and make available the nutrients required for growth. Their work, which ...
Oct 19, 2017
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Medical research
New quality control method to select effective M-beta-CD for treating Neimann-Pick disease
Researchers have developed a quality control method to evaluate the pharmacological activity and potential effectiveness of different preparations of the therapeutic agent methyl-β-cyclodextrin (MβCD). Distinct batches ...
Sep 20, 2017
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