News tagged with malignancy
Related topics: cancer , breast cancer , prostate cancer , cancer cells , carcinoma
A hijacking of healthy cellular circuits
Proteins that control cell growth are often mutated in cancer, and their aberrant signaling drives the wild proliferation of cells that gives rise to tumors. One such protein, the epidermal growth factor receptor (EGFR), ...
Cancer
Apr 08, 2013 |
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XL-184 (Cabozantinib) goes 12-for-12 in colorectal cancer explants
The novel c-MET and VEGFR2 inhibitor, XL-184 (Cabozantinib), resulted in a significant decrease in tumor growth in 12 out of 12 colorectal cancer (CRC) patient-derived explants, with 8 of the explants exhibiting stable disease. ...
Cancer
Apr 08, 2013 |
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KDM1 may represent a new therapeutic target for glioma
Researchers have generated preclinical data demonstrating that the protein KDM1, which functions as a lysine demethylase, is a potential target for glioma treatment, according to Gangadhara R. Sareddy, Ph.D., a postdoctoral ...
Cancer
Apr 08, 2013 |
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Researchers say one specific microrna promotes tumor growth and cancer spread
Researchers at Moffitt Cancer Center have determined that the overexpression of microRNA-155 (miR-155), a short, single strand of ribonucleic acid encoded by the miR-155 host gene, promotes the growth of blood vessels in ...
Cancer
Apr 03, 2013 |
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Cell reprogramming to cure leukaemia and lymphoma
Researchers from the Centre for Genomic Regulation (CRG) in Barcelona reprogramme lymphoma and leukaemia cells to halt their malignancy. Resulting cells remain benign even when no longer subjected to treatment and reduce ...
Cancer
Apr 03, 2013 |
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The metabolic weathervane of cancer
Highly expressed in various cancers and known for its cytoprotective properties, TRAP1 protein has been identified as a potential target for antitumor treatments. As a result of the research conducted by Len Neckers, from ...
Cancer
Apr 01, 2013 |
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Researchers discover brain cancer treatment using genetic material from bone marrow cells
In a first-of-its-kind experiment using microvesicles generated from mesenchymal bone marrow cells (MSCs) to treat cancer, neurological researchers at Henry Ford Hospital have discovered a novel approach for treatment of ...
Cancer
Apr 01, 2013 |
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Researchers design small molecule to disrupt cancer-causing protein
Researchers at Moffitt Cancer Center and colleagues at the University of South Florida have developed a small molecule that inhibits STAT3, a protein that causes cancer. This development could impact the treatment of several ...
Cancer
Mar 26, 2013 |
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Researchers study use of dasatinib for patients with high-risk MDS
Researchers at Moffitt Cancer Center have completed a phase II clinical trial to determine the safety and efficacy of dasatinib for patients with higher-risk myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia, ...
Cancer
Mar 21, 2013 |
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Immortality gene mutation identifies brain tumors, other cancers
Newly identified mutations in a gene that makes cells immortal appear to play a pivotal role in three of the most common types of brain tumors, as well as cancers of the liver, tongue and urinary tract, according to research ...
Cancer
Mar 18, 2013 |
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Tapeworm DNA contains drug weak spots
For the first time, researchers have mapped the genomes of tapeworms to reveal potential drug targets on which existing drugs could act. The genomes provide a new resource that offers faster ways to develop urgently needed ...
Diseases, Conditions, Syndromes
Mar 13, 2013 |
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Asterix's Roman foes: Researchers have a better idea of how cancer cells move and grow
Researchers at the University of Montreal's Institute for Research in Immunology and Cancer (IRIC) have discovered a new mechanism that allows some cells in our body to move together, in some ways like the ...
Cancer
Mar 12, 2013 |
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BRAF inhibitor treatment causes melanoma cells to shift how they produce energy
A multi-institutional study has revealed that BRAF-positive metastatic malignant melanomas develop resistance to treatment with drugs targeting the BRAF/MEK growth pathway through a major change in metabolism. The findings, ...
Cancer
Mar 08, 2013 |
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Study shows increase in liver transplantation for hepatoblastoma
Liver transplantation for hepatoblastoma, the most common liver malignancy in children, is on the rise because more tumors are being detected earlier, improving outcomes for these sick patients, according to a Children's ...
Surgery
Mar 05, 2013 |
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The right dose for oncology
EPFL researchers develop a tool for oncologists using the electrical signature of cancer cells to get just the right treatment dosage for each patient.
Cancer
Mar 04, 2013 |
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