Researchers develop model for better testing, targeting of malignant peripheral nerve sheath tumors
University of Minnesota Medical School researchers from the Masonic Cancer Center, University of Minnesota, in partnership with the University's Brain Tumor Program, have developed a new mouse model of malignant peripheral ...
Genetics
May 20, 2013 |
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Scientists define a new mechanism leading to tumor hypoxia
An article published recently in Tumor Microenvironment and Therapy - an open access journal by Versita, defines a novel mechanism of tumor hypoxia induced by the longitudinal gradient of residual oxygen along tumor vessel ...
Cancer
May 09, 2013 |
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Your immune system: On surveillance in the war against cancer
Predicting outcomes for cancer patients based on tumor-immune system interactions is an emerging clinical approach, and new research from Wake Forest Baptist Medical Center is advancing the field when it comes to the most ...
Genetics
May 09, 2013 |
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Upper GI bleed linked to death from other causes
Individuals who have experienced a major bleed from their stomach or oesophagus (known as an upper gastrointestinal bleed) may be more likely to die from other causes, particularly malignant tumours and cardiovascular disease, ...
Diseases, Conditions, Syndromes
Apr 30, 2013 |
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New approaches to maximize the antitumor activity of interferon
Interferons have antitumor activity and have been used to treat a variety of malignancies, including colorectal and ovarian cancers. However, their effectiveness varies. A clearer understanding of the role ...
Medical research
Apr 16, 2013 |
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New kidney cancer subtypes discovered
Researchers with the Institute of Urologic Oncology and the Department of Urology at UCLA have classified kidney cancer into several unique subtypes, a finding that will help physicians tailor treatment to ...
Cancer
Apr 16, 2013 |
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Gene-expression signature may signify risk for recurrence, metastasis in prostate cancer
A team led by Massachusetts General Hospital (MGH) researchers has identified a genetic signature that appears to reflect the risk of tumor recurrence or spread in men surgically treated for prostate cancer. If confirmed ...
Cancer
Apr 15, 2013 |
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Key bone marrow protein identified as potential new leukemia treatment target
A new study on how the progression of acute lymphocytic leukemia (ALL) is influenced by the bone marrow environment has demonstrated for the first time that targeting a specialized protein known as osteopontin (OPN) may be ...
Cancer
Apr 15, 2013 |
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Association between genetic mutation and risk of death for patients with thyroid cancer
Presence of the genetic mutation BRAF V600E was significantly associated with increased cancer-related death among patients with papillary thyroid cancer (PTC); however, because overall mortality in PTC is low and the association ...
Cancer
Apr 09, 2013 |
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New technology spots drugs' early impact on cancer
A new preclinical technology enables researchers to quickly determine if a particular treatment is effective against gastrointestinal stromal tumors (GISTs), providing a boost to animal research and possibly patient care, ...
Cancer
Apr 09, 2013 |
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A hijacking of healthy cellular circuits
Proteins that control cell growth are often mutated in cancer, and their aberrant signaling drives the wild proliferation of cells that gives rise to tumors. One such protein, the epidermal growth factor receptor (EGFR), ...
Cancer
Apr 08, 2013 |
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XL-184 (Cabozantinib) goes 12-for-12 in colorectal cancer explants
The novel c-MET and VEGFR2 inhibitor, XL-184 (Cabozantinib), resulted in a significant decrease in tumor growth in 12 out of 12 colorectal cancer (CRC) patient-derived explants, with 8 of the explants exhibiting stable disease. ...
Cancer
Apr 08, 2013 |
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KDM1 may represent a new therapeutic target for glioma
Researchers have generated preclinical data demonstrating that the protein KDM1, which functions as a lysine demethylase, is a potential target for glioma treatment, according to Gangadhara R. Sareddy, Ph.D., a postdoctoral ...
Cancer
Apr 08, 2013 |
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Researchers say one specific microrna promotes tumor growth and cancer spread
Researchers at Moffitt Cancer Center have determined that the overexpression of microRNA-155 (miR-155), a short, single strand of ribonucleic acid encoded by the miR-155 host gene, promotes the growth of blood vessels in ...
Cancer
Apr 03, 2013 |
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The metabolic weathervane of cancer
Highly expressed in various cancers and known for its cytoprotective properties, TRAP1 protein has been identified as a potential target for antitumor treatments. As a result of the research conducted by Len Neckers, from ...
Cancer
Apr 01, 2013 |
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