Researchers discover endogenous antibiotic in the brain
Scientists from the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg have discovered that immune cells in the brain can produce a substance that prevents bacterial growth: namely itaconic acid. ...
Medical research
May 06, 2013 |
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'Traffic' in our cells works both for and against us
A mechanism that permits essential substances to enter our cells while at the same time removing from them harmful components also has a "down side." This negative aspect prevents vital drugs, such as anti-cancer drugs, from ...
Medical research
May 01, 2013 |
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How the brain folds to fit
During fetal development of the mammalian brain, the cerebral cortex undergoes a marked expansion in surface area in some species, which is accommodated by folding of the tissue in species with most expanded ...
Neuroscience
Apr 26, 2013 |
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Recipe for large numbers of stem cells requires only one ingredient
Stem cells and tissue-specific cells can be grown in abundance from mature mammalian cells simply by blocking a certain membrane protein, according to scientists at the University of Pittsburgh School of Medicine and the ...
Medical research
Apr 17, 2013 |
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Immune response linked to key enzyme
(Medical Xpress)—A previously unknown function of a family of enzymes familiar to biologists may contribute to scientists' understanding of signaling molecules involved in the body's immune response and ...
Immunology
Apr 12, 2013 |
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Genetic master controls expose cancers' Achilles' heel
In a surprising finding that helps explain fundamental behaviors of normal and diseased cells, Whitehead Institute scientists have discovered a set of powerful gene regulators dubbed "super-enhancers" that control cell state ...
Cancer
Apr 11, 2013 |
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Separate lives: Neuronal and organismal lifespans decoupled
(Medical Xpress)—Replicative aging (also known as replicative senescence) causes mammalian cells to undergo a process of growth arrest dependent on telomeres (the shortening of repeated sequences at the ends o ...
Neuroscience
Mar 27, 2013 |
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Transmission routes of spreading protein particles
In diseases like Alzheimer's and Parkinson's endogenous proteins accumulate in the brain, eventually leading to the death of nerve cells. These deposits, which consist of abnormally formed proteins, are supposed to migrate ...
Neuroscience
Mar 27, 2013 |
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Protein in fat cells that stimulates inflammatory signaling helps put gears in motion for onset of diet-induced obesity
Poor diet and lifestyle choices set the stage for obesity and diabetes, but the immune system plays a relatively underappreciated role in accelerating this process. Metabolic changes in fat cells stimulate ...
Medical research
Mar 15, 2013 |
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Cellular bells: Key step in manufacture of red blood cells decoded
A healthy adult must generate as many as one hundred billion new red blood cells each day, to maintain the numbers circulating in his blood. A team of EPFL researchers has identified a key step in the process by which red ...
Medical research
Mar 14, 2013 |
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Synthetic corkscrew peptide kills antibiotic-resistant Gram-negative bacteria
An engineered peptide provides a new prototype for killing an entire category of resistant bacteria by shredding and dissolving their double-layered membranes, which are thought to protect those microbes from antibiotics.
Medical research
Jan 24, 2013 |
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Search for epigenetic decoder leads scientists to Rett Syndrome
(Medical Xpress)—A few years ago, scientists discovered an unexpected layer of information woven into the genetic code – a nucleotide called 5-hydroxymethylcytosine, or 5hmC. Its meaning was unknown at the time, but a ...
Medical research
Dec 21, 2012 |
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Protein creates paths for growing nerve cells
Working with mice, Johns Hopkins scientists have discovered that a particular protein helps nerve cells extend themselves along the spinal cord during mammalian development. Their results shed light on the ...
Neuroscience
Dec 19, 2012 |
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Researchers find model system to study promising cancer drug
Researchers have found that the budding yeast (Saccharomyces cerevisiae) is an acceptable model system to study KP1019, an anti-cancer drug that uses ruthenium, a rare metal, a new study found. Researchers had previously been i ...
Medications
Dec 18, 2012 |
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A key gene for brain development
(Medical Xpress)—Neurobiologists at the Research institute of Molecular Pathology (IMP) in Vienna have discovered one of the key genes required to make a brain. Mutations in this gene, called TUBB5, cause ...
Genetics
Dec 14, 2012 |
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