Separate lives: Neuronal and organismal lifespans decoupled
(Medical Xpress)—Replicative aging (also known as replicative senescence) causes mammalian cells to undergo a process of growth arrest dependent on telomeres (the shortening of repeated sequences at the ends o ...
Neuroscience
Mar 27, 2013 |
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Blood-brain barrier building blocks forged from human stem cells
The blood-brain barrier -- the filter that governs what can and cannot come into contact with the mammalian brain -- is a marvel of nature. It effectively separates circulating blood from the fluid that bathes the brain, ...
Medical research
Jun 24, 2012 |
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Brain structure adapts to environmental change
Scientists have known for years that neurogenesis takes place throughout adulthood in the hippocampus of the mammalian brain. Now Columbia researchers have found that under stressful conditions, neural stem cells in the adult ...
Neuroscience
Jun 13, 2011 |
4.7 / 5 (7) |
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Recipe for large numbers of stem cells requires only one ingredient
Stem cells and tissue-specific cells can be grown in abundance from mature mammalian cells simply by blocking a certain membrane protein, according to scientists at the University of Pittsburgh School of Medicine and the ...
Medical research
Apr 17, 2013 |
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Genetic master controls expose cancers' Achilles' heel
In a surprising finding that helps explain fundamental behaviors of normal and diseased cells, Whitehead Institute scientists have discovered a set of powerful gene regulators dubbed "super-enhancers" that control cell state ...
Cancer
Apr 11, 2013 |
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'Unnatural' chemical allows researchers to watch protein action in brain cells
Researchers at the Salk Institute have been able to genetically incorporate "unnatural" amino acids, such as those emitting green fluorescence, into neural stem cells, which then differentiate into brain neurons with the ...
Medical research
Jul 07, 2011 |
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Cellular bells: Key step in manufacture of red blood cells decoded
A healthy adult must generate as many as one hundred billion new red blood cells each day, to maintain the numbers circulating in his blood. A team of EPFL researchers has identified a key step in the process by which red ...
Medical research
Mar 14, 2013 |
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Scientists uncover a novel cooperative effort to stop cancer spread
(Medical Xpress)—Scientists from the Florida campus of The Scripps Research Institute (TSRI) have uncovered a group of what have been considered relatively minor regulators in the body that band together to suppress the ...
Cancer
Nov 28, 2012 |
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Immune response linked to key enzyme
(Medical Xpress)—A previously unknown function of a family of enzymes familiar to biologists may contribute to scientists' understanding of signaling molecules involved in the body's immune response and ...
Immunology
Apr 12, 2013 |
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Natural process activating brain's immune cells could point way to repairing damaged brain tissue
The brain's key "breeder" cells, it turns out, do more than that. They secrete substances that boost the numbers and strength of critical brain-based immune cells believed to play a vital role in brain health. This finding ...
Neuroscience
Oct 21, 2012 |
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GABA signaling prunes back copious 'provisional' synapses during neural circuit assembly
Quite early in its development, the mammalian brain has all the raw materials on hand to forge complex neural networks. But forming the connections that make these intricate networks so exquisitely functional is a process ...
Neuroscience
Jan 03, 2012 |
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A key gene for brain development
(Medical Xpress)—Neurobiologists at the Research institute of Molecular Pathology (IMP) in Vienna have discovered one of the key genes required to make a brain. Mutations in this gene, called TUBB5, cause ...
Genetics
Dec 14, 2012 |
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Scientists identify a surprising new source of cancer stem cells
Whitehead Institute researchers have discovered that a differentiated cell type found in breast tissue can spontaneously convert to a stem-cell-like state, the first time such behavior has been observed in mammalian cells. ...
Cancer
Apr 11, 2011 |
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Novel treatment protects mice against malaria; approach may work in humans as well
Malaria is a major global health concern, and researchers are in need of new therapeutic approaches. To address this concern, a study published Oct. 26 in the online journal PLoS ONE reveals new information about the host c ...
Medical research
Oct 26, 2011 |
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New components of antiviral pathway discovered
Scientists studying how mammals detect microbes have discovered new components in a crucial pathway that allows immune cells to detect viral invaders. Their research not only deepens the understanding of antiviral responses, ...
Medical research
Dec 22, 2011 |
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