Landmark study in blood stem cell transplant
(Medical Xpress)—Before all the excitement about embryonic stem cells, doctors were using hematopoetic – that is, blood-forming—stem cells. Hematopoetic stem cells can replenish all the types of cells in the blood, ...
Medical research
Jan 04, 2013 |
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Mitochondrial components are a possible trigger of auto-inflammatory illnesses
(Medical Xpress)—Many illnesses, including psoriasis, include inflammatory responses that occur without an apparent infection and worsen with stress. In a study using cultured human mast cells in vitro and in rats, researchers ...
Inflammatory disorders
Jan 02, 2013 |
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Scientists shed new light on mechanisms of T-ALL, a form of leukemia that primarily affects children
Acute lymphatic leukemia (ALL) is the most common cancer in children under the age of 14 years. With optimum treatment, approximately 75 % of children are currently cured, but the treatment consists of severe chemotherapy ...
Cancer
Dec 23, 2012 |
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Cultural, social factors identified as barriers to minority participation in stem cell donation
New research examining the role of race and ethnicity in an individual's decision to become a donor for hematopoietic cell transplantation (HCT) identifies several factors associated with varied participation rates in national ...
Other
Dec 20, 2012 |
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Scientists identify new biomarker for cancer in bone marrow: Promise for patients of multiple myeloma
Singapore scientists have identified FAIM, a molecule that typically prevents cell death, as a potential biomarker to identify an incurable form of cancer in the bone marrow. Patients with this form of cancer usually do not ...
Cancer
Dec 13, 2012 |
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Pre-transplant umbilical cord blood expansion speeds establishment of new blood supply in patients
Donated umbilical cord blood establishes a new blood supply in patients more quickly after transplantation when it is first expanded in the lab on a bed of cells that mimics conditions in the bone marrow, researchers report ...
Medical research
Dec 12, 2012 |
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US doctors defeat leukemia with modified HIV (Update)
US doctors say they have saved a seven-year-old girl who was close to dying from leukemia by pioneering the use of an unlikely ally: a modified form of the HIV virus.
Medical research
Dec 11, 2012 |
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Leukemia patients remain in remission more than two years after engineered T cell therapy
Nine of twelve leukemia patients who received infusions of their own T cells after the cells had been genetically engineered to attack the patients' tumors responded to the therapy, which was pioneered by scientists in the ...
Cancer
Dec 10, 2012 |
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Temple scientists target DNA repair to eradicate leukemia stem cells
Despite treatment with imatinib, a successful drug that targets chronic myeloid leukemia (CML), a deadly type of cancer, some patients may continue to be at risk for relapse because a tiny pool of stem cells is resistant ...
Cancer
Dec 09, 2012 |
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Combination therapy using JAK2 and HSP90 inhibitors increased efficacy in myelofibrosis in vivo
Researchers have demonstrated that combination therapy with PU-H71 and ruxolitinib increases the durability and effectiveness of a treatment that had previously shown limited utility for patients with myelofibrosis.
Cancer
Dec 09, 2012 |
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Targeting histone deacetylases as a new strategy for graft versus host disease prevention
New research shows that the addition of the oral anti-cancer agent vorinostat to standard therapy given before, during, and after hematopoietic stem cell transplantation (HSCT) may safely reduce the incidence and severity ...
Medical research
Dec 09, 2012 |
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More than a third of high-risk leukemia patients respond to an experimental new drug
A new drug for patients with acute myeloid leukemia (AML) marked by a specific type of genetic mutation has shown surprising promise in a Phase II clinical trial. In more than a third of participants, the leukemia was completely ...
Medications
Dec 09, 2012 |
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New drug cuts risk of deadly transplant side effect in half
A new class of drugs reduced the risk of patients contracting a serious and often deadly side effect of lifesaving bone marrow transplant treatments, according to a study from researchers at the University of Michigan Comprehensive ...
Medical research
Dec 09, 2012 |
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Pre-clinical data shows Angiocidin effective against leukemia
Angiocidin, a novel tumor-inhibiting protein, has been shown to reduce acute myeloid leukemia (AML) cells in vivo by almost two-thirds in pre-clinical experiments.
Cancer
Dec 09, 2012 |
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Gene therapy as a new option for bone defects
(Medical Xpress)—Gene therapy involving modified stem cells obtained from fatty tissue and bone marrow could represent a new option for the treatment of severe orthopaedic injuries to the extremities. This treatment has ...
Medical research
Dec 07, 2012 |
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