New insights into functionality of cystic fibrosis protein
CFTR is an important protein that, when mutated, causes the life-threatening genetic disease cystic fibrosis. A study in The Journal of General Physiology (JGP) details how an accidental discovery has provided ...
Medical research
Sep 26, 2012 |
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Study: Prazosin inhibits endocytic sorting
In a study just published in Proceedings of the National Academy of Sciences, Dr Ulrike Eggert et al. demonstrated that the drug Prazosin inhibits endocytic sorting.
Medical research
Sep 13, 2012 |
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Tension on gut muscles induces cell invasion in zebrafish intestine, mimicking cancer metastasis
The stiffness of breast tissue is increasingly recognized as an important factor explaining the onset of breast cancer. Stiffening induces molecular changes that promote cancerous behavior in cells. Bioengineering ...
Cancer
Sep 07, 2012 |
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Genetic disease linked to protein build-up
Mutations of the gene Lmna previously thought to be directly responsible for a group of laminopathies—serious developmental conditions including premature aging and a form of muscular dystrophy—in fact ...
Medical research
Aug 29, 2012 |
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It must be important but what does it do? The strange case of UCP2
When uncoupling proteins are active, mitochondria produce heat instead of ATP. This may be useful under certain circumstances, such as when an animal is hibernating. But non-hibernating animals also have them. Particularly ...
Medical research
Aug 17, 2012 |
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Can you hear me now? New strategy discovered to prevent hearing loss
If you're concerned about losing your hearing because of noise exposure (earbud deafness syndrome), a new discovery published online in the FASEB Journal offers some hope. That's because scientists from Germany and Canada ...
Medical research
Jul 06, 2012 |
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Arsenic for better drugs and cleaner crops
Research carried out at the University of Gothenburg may lead to more effective arsenic-containing drugs. The results may also lead to more resistant plants, and crops with a limited absorption and storage of arsenic.
Medications
Jun 25, 2012 |
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Fighting cancer with the immune system
The human immune system has a natural ability to identify and attack tumor cells. Natural killer (NK) cells are innate immune cells that are particularly effective at killing tumor cells due to their ability to secrete cytotoxic ...
Cancer
Jun 11, 2012 |
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Researchers uncover genes at fault for cystic fibrosis-related intestinal obstruction
Researchers at Johns Hopkins have identified a gene that modifies the risk of newborns with cystic fibrosis (CF) developing neonatal intestinal obstruction, a potentially lethal complication of CF. Their findings, which appeared ...
Genetics
Apr 23, 2012 |
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Researchers identify key regulator of inflammatory response
(Medical Xpress) -- Researchers at Boston University School of Medicine (BUSM) have identified a gene that plays a key role in regulating inflammatory response and homeostasis. These findings could help lead to the development ...
Inflammatory disorders
Apr 12, 2012 |
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Study reveals insight into how key protein protects against viral infections
Scientists from the University of Utah School of Medicine have discovered that a mouse protein called IFITM3 contributes to the body's defense against some types of viral infections by binding to an enzyme responsible for ...
Immunology
Apr 02, 2012 |
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Hot on the trail of metabolic diseases and resistance to antibiotics
Proteins belonging to the large and important family of ABC transporters have been associated with metabolic diseases and can cause resistance to antibiotics. Biochemists from the University of Zurich and the NCCR Structural ...
Medical research
Mar 28, 2012 |
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New research could provide roadmap for more effective drug discovery for cystic fibrosis
A recent study led by Gergely Lukacs, a professor at McGill University's Faculty of Medicine, Department of Physiology, and published in the January issue of Cell, has shown that restoring normal function to the mutant gene p ...
Medical research
Mar 12, 2012 |
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Perception and preference may have genetic link to obesity
About five years ago, animal studies first revealed the presence of entirely novel types of oral fat sensors or receptors on the tongue. Prior to this time, it was believed that fats were perceived only by flavor and texture ...
Health
Mar 05, 2012 |
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Scientists identify protein that sends 'painful touch' signals
In two landmark papers in the journal Nature this week, scientists at The Scripps Research Institute report that they have identified a class of proteins that detect "painful touch."
Medical research
Feb 19, 2012 |
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