News tagged with metabolic switch

Researchers find molecular switch turning on self-renewal of liver damage

The liver is one of the few organs in our body that can regenerate itself, but how it occurs is a biological mystery. New research from BRIC, University of Copenhagen and the Finsen Laboratory, Rigshospitalet, ...

Medical research Mar 07, 2013 | 5 / 5 (1) | 0

Study shows key enzyme missing from aggressive form of breast cancer

A groundbreaking new study led by the University of Kentucky Markey Cancer Center's Dr. Peter Zhou found that triple-negative breast cancer cells are missing a key enzyme that other cancer cells contain—providing insight ...

Cancer Feb 28, 2013 | 5 / 5 (1) | 0 |

Stem cell survival strategy key to blood and immune system health

Stem cells of the aging bone marrow recycle their own molecules to survive and keep replenishing the blood and immune systems as the body ages, researchers at UC San Francisco (UCSF) have discovered.

Medical research Feb 14, 2013 | 5 / 5 (3) | 0 |

The X factor in liver metabolism

After you eat, your liver switches from producing glucose to storing it. At the same time, a cellular signaling pathway known as the unfolded protein response (UPR) is transiently activated, but it is not clear how this pathway ...

Medical research Dec 21, 2012 | not rated yet | 0

More than 3,000 epigenetic switches control daily liver cycles

(Medical Xpress)—When it's dark, and we start to fall asleep, most of us think we're tired because our bodies need rest. Yet circadian rhythms affect our bodies not just on a global scale, but at the level ...

Genetics Dec 11, 2012 | 4.8 / 5 (5) | 0 |

Targeting downstream proteins in cancer-causing pathway shows promise in cell, animal model

The cancer-causing form of the gene Myc alters the metabolism of mitochondria, the cell's powerhouse, making it dependent on the amino acid glutamine for survival. In fact, 40 percent of all "hard-to-treat" cancers have a ...

Cancer Nov 13, 2012 | 5 / 5 (1) | 0

Scientists find molecular link to obesity and insulin resistance in mice

Flipping a newly discovered molecular switch in white fat cells enabled mice to eat a high-calorie diet without becoming obese or developing the inflammation that causes insulin resistance, report scientists ...

Medical research Sep 27, 2012 | 5 / 5 (5) | 0 |

Liver fat gets a wake-up call that maintains blood sugar levels

A Penn research team, led by Mitchell Lazar, MD, PhD, director of the Institute for Diabetes, Obesity, and Metabolism at the Perelman School of Medicine, University of Pennsylvania, reports in Nature Medicine that m ...

Medical research May 06, 2012 | 4.5 / 5 (2) | 1 |

Scientists redraw the blueprint of the body's biological clock

The discovery of a major gear in the biological clock that tells the body when to sleep and metabolize food may lead to new drugs to treat sleep problems and metabolic disorders, including diabetes.

Medical research Apr 06, 2012 | 5 / 5 (4) | 0 |

New discovery may lead to safer treatments for asthma, allergies and arthritis

Scientists have discovered a missing link between the body's biological clock and sugar metabolism system, a finding that may help avoid the serious side effects of drugs used for treating asthma, allergies and arthritis.

Arthritis & Rheumatism Dec 19, 2011 | 5 / 5 (1) | 0 |

Researchers discover 'master switch' gene for obesity, diabetes

A team of researchers, led by King's College London and the University of Oxford, have found that a gene linked to type 2 diabetes and cholesterol levels is in fact a 'master regulator' gene, which controls the behaviour ...

Genetics May 15, 2011 | 4.8 / 5 (5) | 1 |

Evolutionary conservation of fat metabolism pathways

By virtue of having survived, all animals-from flies to man-share a common expertise. All can distinguish times of plenty from famine and adjust their metabolism or behavior accordingly. Failure to do so signals ...

Medical research May 12, 2011 | 5 / 5 (1) | 0 |