News tagged with metabolites
Researchers discover new link between heart disease and red meat
A compound abundant in red meat and added as a supplement to popular energy drinks has been found to promote atherosclerosis – or the hardening or clogging of the arteries – according to Cleveland Clinic ...
Cardiology
Apr 07, 2013 |
4.8 / 5 (18) |
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Amino acid consumption associated with how fast cancer cells divide
For almost a century, researchers have known that cancer cells have peculiar appetites, devouring glucose in ways that normal cells do not. But glucose uptake may tell only part of cancer's metabolic story. Researchers from ...
Cancer
May 24, 2012 |
5 / 5 (5) |
1
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New powerful tool measures metabolites in living cells
By engineering cells to express a modified RNA called "Spinach," researchers have imaged small-molecule metabolites in living cells and observed how their levels change over time. Metabolites are the products of individual ...
Medical research
Mar 08, 2012 |
5 / 5 (1) |
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Surprising culprits behind cell death from fat and sugar overload
Excess nutrients, such as fat and sugar, don't just pack on the pounds but can push some cells in the body over the brink. Unable to tolerate this "toxic" environment, these cells commit suicide.
Medical research
Jul 05, 2011 |
4.6 / 5 (9) |
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Anti-smoking ads with strong arguments, not flashy editing, trigger part of brain involving behavior change
Researchers from the Perelman School of Medicine at the University of Pennsylvania have shown that an area of the brain that initiates behavioral changes had greater activation in smokers who watched anti-smoking ads with ...
Neuroscience
Apr 23, 2013 |
5 / 5 (2) |
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Contaminated diet contributes to phthalate and bisphenol A exposure
While water bottles may tout BPA-free labels and personal care products declare phthalates not among their ingredients, these assurances may not be enough. According to a study published February 27 in the ...
Health
Feb 27, 2013 |
not rated yet |
0
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Lack of key enzyme in the metabolism of folic acid leads to birth defects
Researchers at The University of Texas at Austin have discovered that the lack of a critical enzyme in the folic acid metabolic pathway leads to neural tube birth defects in developing embryos.
Medical research
Jan 17, 2013 |
not rated yet |
0
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Researchers find new target for Alzheimer's drug development
Researchers at the University of Minnesota's Center for Drug Design have developed a synthetic compound that, in a mouse model, successfully prevents the neurodegeneration associated with Alzheimer's disease.
Alzheimer's disease & dementia
Dec 03, 2012 |
5 / 5 (1) |
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Study finds high exposure to food-borne toxins
In a sobering study published in the journal Environmental Health, researchers at UC Davis and UCLA measured food-borne toxin exposure in children and adults by pinpointing foods with high levels of toxic compounds and de ...
Health
Nov 13, 2012 |
5 / 5 (1) |
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Researchers identify novel metabolic programs driving aggressive brain tumors
Researchers at Moffitt Cancer Center have identified metabolic signatures that may pave the way for personalized therapy in glioma, a type of tumor that starts in the brain.
Cancer
Nov 09, 2012 |
4 / 5 (1) |
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Mice with 'humanized' livers improve early drug testing
Stanford University School of Medicine scientists have used bioengineered mice with livers composed largely of human cells to characterize a drug about to enter early-stage clinical development for combating hepatitis C.
Medical research
Oct 31, 2012 |
3 / 5 (1) |
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New model to explain the role of dopamine in immune regulation described
Dopamine is a neurotransmitter that is associated with emotions, movement, and the brain's pleasure and reward system. In the current issue of Advances in Neuroimmune Biology, investigators provide a broad overview of the ...
Immunology
Oct 11, 2012 |
5 / 5 (1) |
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Popular HIV drug may cause memory declines
The way the body metabolizes a commonly prescribed anti-retroviral drug that is used long term by patients infected with HIV may contribute to cognitive impairment by damaging nerve cells, a new Johns Hopkins research suggests.
HIV & AIDS
Sep 27, 2012 |
5 / 5 (1) |
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New more-sensitive blood test catches recurring breast cancer a year earlier
A new blood test is twice as sensitive and can detect breast cancer recurrence a full year earlier than current blood tests, according to a scientist who reported here today at the 243rd National Meeting & Exposition of the Ame ...
Cancer
Mar 28, 2012 |
not rated yet |
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Circadian rhythms have profound influence on metabolic output, study reveals
By analyzing the hundreds of metabolic products present in the liver, researchers with the UC Irvine Center for Epigenetics & Metabolism have discovered that circadian rhythms – our own body clock – greatly control ...
Medical research
Mar 19, 2012 |
4 / 5 (1) |
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Metabolite
Metabolites are the intermediates and products of metabolism. The term metabolite is usually restricted to small molecules. A primary metabolite is directly involved in normal growth, development, and reproduction. Alcohol is an example of a primary metabolite produced in large-scale by industrial microbiology. A secondary metabolite is not directly involved in those processes, but usually has an important ecological function. Examples include antibiotics and pigments. Some antibiotics use primary metabolites as precursors, such as actinomycin which is created from the primary metabolite, tryptophan.
Examples of primary metabolites produced by industrial microbiology:
The metabolome forms a large network of metabolic reactions, where outputs from one enzymatic chemical reaction are inputs to other chemical reactions.
Metabolites from chemical compounds, whether inherent or pharmaceutical, are formed as part of the natural biochemical process of degrading and eliminating the compounds. The rate of degradation of a compound is an important determinant of the duration and intensity of its action. Profiling metabolites of pharmaceutical compounds, drug metabolism, is an important part of drug discovery, leading to an understanding of any undesirable side effects.
For more information about Metabolite, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
