Relief could be on the way for people with painful hand osteoarthritis after a Monash University and Alfred Health-led study found an affordable existing drug can help. Until now there has been no effective treatment.
Oct 13, 2023
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89
More than half of cancer survivors suffer from cognitive impairment from chemotherapy that lingers for months or years after the cancer is gone. In a new study explaining the cellular mechanisms behind this condition, scientists ...
Dec 6, 2018
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2070
People taking a common rheumatoid arthritis medicine are not at increased risk of liver damage if they stick to 14 units of alcohol a week or fewer, a new study from The University of Manchester has found.
Mar 27, 2017
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With a cure rate approaching 90 percent, acute lymphoblastic leukemia (ALL) - the most common type of childhood cancer - is often hailed as one of the "success stories" of modern cancer treatment. But up to 20 percent of ...
Apr 25, 2016
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Initiating early treatment benefits patients who have not fully developed rheumatoid arthritis, but who are manifesting preliminary stages of the disease. This is what researchers from the Leiden University Medical Centre ...
Jul 22, 2022
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Tackling unsolved problems is a cornerstone of scientific research, propelled by the power and promise of new technologies. Indeed, one of the shiniest tools in the biomedical toolkit these days is the genome editing system ...
Jul 13, 2018
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Methotrexate is a common drug with a long history; for the past 40 years, it's been used to treat a range of diseases. Today it is the most commonly used drug for systemic rheumatic diseases worldwide and is the first drug ...
Feb 17, 2020
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Patients suffering from rheumatoid arthritis are treated for around six months with the standard anti-rheumatic agent methotrexate, to which many patients respond very well. However, if they do not respond and no remission ...
Jun 19, 2017
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In its final Phase III clinical trial, a new drug for treating rheumatoid arthritis has proved to be at least as effective as the current "gold standard" treatment for this autoimmune disease. This opens up new treatment ...
Aug 25, 2022
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Up to a third of patients taking methotrexate—a common treatment for immune mediated inflammatory conditions such as rheumatoid arthritis and psoriasis/psoriatic arthritis—failed to achieve an adequate immune response ...
May 25, 2021
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13
Methotrexate (rINN) ( /mɛθɵˈtrɛkseɪt/), abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate began to replace the more toxic antifolate aminopterin starting in the 1950s. The drug was developed by Yellapragada Subbarao.
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