News tagged with methotrexate
Newer, more expensive psoriasis drugs only slightly more effective than older therapies under real world conditions
More expensive biologic treatments for psoriasis were only marginally more effective than standard treatments, according to a new study led by researchers in the Perelman School of Medicine at the University of Pennsylvania. ...
Diseases, Conditions, Syndromes
Apr 30, 2012 |
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First study on long-term cognitive effects of breast cancer CMF chemotherapy finds subtle impairment
Dutch investigators have reported that women who received CMF chemotherapy (a combination regimen including the drugs cyclophosphamide, methotrexate, and 5-fluorouracil) for breast cancer between 1976 and 1995 scored worse ...
Cancer
Feb 27, 2012 |
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Cancer drugs help the hardest cases of Pompe disease
Kids with Pompe disease fail because of a missing enzyme, GAA, that leads to dangerous sugar build-up, which affects muscles and movement. An enzyme replacement treatment pioneered at Duke University has saved many lives, ...
Genetics
Jan 05, 2012 |
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Pharmacogenomics study finds rare gene variants critical for personalized drug treatment
The use of genetic tests to predict a patient's response to drugs is increasingly important in the development of personalized medicine. But genetic tests often only look for the most common gene variants. In a pharmacogenomics ...
Genetics
Dec 05, 2011 |
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Common rheumatoid arthritis and psoriasis medications are associated with reduced diabetes risk
Individuals with systemic inflammatory conditions, such as rheumatoid arthritis (RA) and psoriasis, experience a 1.5 to 2-fold increased rate of cardiovascular disease. Previous research suggests that inflammation and insulin ...
Diseases, Conditions, Syndromes
Jun 21, 2011 |
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Ultrasound findings can improve classification of RA
(HealthDay)—Compared to clinical diagnosis of synovitis, ultrasound-detected synovitis provides either improved sensitivity or specificity when used with the American College of Rheumatology/European League ...
Arthritis & Rheumatism
May 15, 2013 |
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Fertility after ectopic pregnancy: Study finds reassuring evidence on different treatments
The first randomised trial to compare treatments for ectopic pregnancies has found no significant differences in subsequent fertility between medical treatment and conservative surgery on one hand, and conservative or radical ...
Obstetrics & gynaecology
Mar 12, 2013 |
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Newly approved oral medication slows rheumatoid arthritis joint damage
A Phase 3 clinical trial demonstrates that tofacitinib improves disease activity and inhibits progression of joint damage in rheumatoid arthritis (RA) patients who did not respond to methotrexate (MTX). Results of the 12-month ...
Arthritis & Rheumatism
Jan 24, 2013 |
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Rheumatism drug also effective at half dose
The treatment of moderately active rheumatoid arthritis with the tumour necrosis factor inhibitor Etanercept achieves excellent success in more than 80 per cent of patients. With this method, the success ...
Arthritis & Rheumatism
Jan 18, 2013 |
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Data suggest smoking doesn't impact RA treatment response
(HealthDay)—For patients with early rheumatoid arthritis (RA), smoking status does not impact treatment response to early combination therapy or initial methotrexate treatment with step-up therapy, according ...
Arthritis & Rheumatism
Dec 21, 2012 |
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Experimental graft-vs.-host disease treatment equivalent to standard care in Phase 3 trial
An experimental drug combination for preventing graft-versus-host disease (GVHD) was not significantly better than the standard regimen on key endpoints, according to a report of a phase 3 trial at the American Society of ...
Cancer
Dec 10, 2012 |
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Xeljanz approved for rheumatoid arthritis
(HealthDay)—Xeljanz (tofacitinib) has been approved by the U.S. Food and Drug Administration to treat symptoms of rheumatoid arthritis (RA) among people who can't tolerate, or haven't been helped by, the drug methotrexate.
Arthritis & Rheumatism
Nov 07, 2012 |
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Women whose first pregnancy was ectopic have fewer children
Women whose first pregnancy is ectopic are likely to have fewer children in the following 20-30 years than women whose first pregnancy ends in a delivery, miscarriage or abortion, according to results from a study of nearly ...
Obstetrics & gynaecology
Oct 17, 2012 |
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Methotrexate use linked to reduced mortality in RA
(HealthDay)—Use of methotrexate for one year or more is associated with a reduction in the risk of mortality for patients with rheumatoid arthritis (RA), according to a study published online Oct. 8 in ...
Arthritis & Rheumatism
Oct 14, 2012 |
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Choice of psoriasis treatment affects CVD event rates
(HealthDay)—Compared with other anti-psoriatic therapies, systemic anti-inflammatory treatment of patients with severe psoriasis with biologic agents or methotrexate is associated with a lower combined ...
Immunology
Sep 27, 2012 |
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Methotrexate
Methotrexate (rINN) ( /mɛθɵˈtrɛkseɪt/), abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate began to replace the more toxic antifolate aminopterin starting in the 1950s. The drug was developed by Yellapragada Subbarao.
For more information about Methotrexate, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
