Team finds antibody that transforms bone marrow stem cells directly into brain cells
In a serendipitous discovery, scientists at The Scripps Research Institute (TSRI) have found a way to turn bone marrow stem cells directly into brain cells.
Medical research
Apr 22, 2013 |
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Structure of a bond formed by two proteins critical for hearing and balance described for the first time
Researchers have mapped the precise 3-D atomic structure of a thin protein filament critical for cells in the inner ear and calculated the force necessary to pull it apart.
Medical research
Nov 07, 2012 |
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Using rabies virus, researcher tracks inputs to dopamine neurons
A genetically-modified version of the rabies virus is helping scientists at Harvard to trace neural pathways in the brain, a research effort that could one day lead to treatments for Parkinson's disease and addiction.
Neuroscience
Jun 06, 2012 |
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Sending out an SOS: How telomeres incriminate cells that can't divide
The well-being of living cells requires specialized squads of proteins that maintain order. Degraders chew up worn-out proteins, recyclers wrap up damaged organelles, and-most importantly-DNA repair crews ...
Medical research
Mar 12, 2012 |
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Mutation causing wrong-way plumbing explains one type of blue-baby syndrome
Total anomalous pulmonary venous connection (TAPVC), one type of "blue baby" syndrome, is a potentially deadly congenital disorder that occurs when pulmonary veins don't connect normally to the left atrium of the heart. This ...
Medical research
May 12, 2013 |
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Rare, lethal childhood disease tracked to protein
A team of international researchers led by Northwestern Medicine scientists has identified how a defective protein plays a central role in a rare, lethal childhood disease known as Giant Axonal Neuropathy, or GAN. The finding ...
Medical research
Apr 29, 2013 |
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Researchers identify and block protein that interferes with appetite-suppressing hormone
Ever since the appetite-regulation hormone called leptin was discovered in 1994, scientists have sought to understand the mechanisms that control its action. It was known that leptin was made by fat cells, reduced appetite ...
Medical research
Apr 17, 2013 |
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Fatheads: How neurons protect themselves against excess fat
We're all fatheads. That is, our brain cells are packed with fat molecules, more of them than almost any other cell type. Still, if the brain cells' fat content gets too high, they'll be in trouble. In a recent study in mice, ...
Medical research
Apr 08, 2013 |
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Loss of tumor suppressor SPOP releases cancer potential of SRC-3
Mutations in a protein called SPOP (speckle-type POZ protein) disarm it, allowing another protein called steroid receptor coactivator-3 (SRC-3) to encourage the proliferation and spread of prostate cancer cells, said researchers ...
Cancer
Apr 01, 2013 |
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Eat too much? Maybe it's in the blood
Bone marrow cells that produce brain-derived eurotrophic factor (BDNF), known to affect regulation of food intake, travel to part of the hypothalamus in the brain where they "fine-tune" appetite, said researchers from Baylor ...
Medical research
Feb 26, 2013 |
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Preclinical study identifies 'master' proto-oncogene that regulates ovarian cancer metastasis
Scientists at The University of Texas MD Anderson Cancer Center have discovered the signaling pathway whereby a master regulator of cancer cell proteins – known as Src – leads to ovarian cancer progression when exposed ...
Cancer
Jan 29, 2013 |
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Diabetes drug could hold promise for lung cancer patients
Ever since discovering a decade ago that a gene altered in lung cancer regulated an enzyme used in therapies against diabetes, Reuben Shaw has wondered if drugs originally designed to treat metabolic diseases ...
Cancer
Jan 29, 2013 |
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New technique catalogs lymphoma-linked genetic variations
(Medical Xpress)—As anyone familiar with the X-Men knows, mutants can be either very good or very bad—or somewhere in between. The same appears true within cancer cells, which may harbor hundreds of mutations that set ...
Cancer
Dec 27, 2012 |
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A new type of nerve cell found in the brain
Scientists at Karolinska Institutet in Sweden, in collaboration with colleagues in Germany and the Netherlands, have identified a previously unknown group of nerve cells in the brain. The nerve cells regulate ...
Neuroscience
Dec 21, 2012 |
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COUP-TFII sparks prostate cancer progression
Prostate cancer presents a dilemma for patients and the physicians who treat them. Which cancers are essentially indolent and present no risk and which are life threatening? Which can be watched and which need aggressive ...
Cancer
Nov 28, 2012 |
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