New research has shown that the antidepressant sertraline inhibits the growth of cancer cells. It acts on a metabolic addiction that allows different types of cancer to grow. This is shown by a study on cell cultures and ...
Nov 17, 2020
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A novel agent that targets a mutated form of the KRAS gene—the most commonly altered oncogene in human cancers and one long considered "undruggable"—shrank tumors in most patients in a clinical trial with manageable side ...
Oct 25, 2020
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Scientists cannot be expected to drop everything they're working on to turn their attention to beating COVID-19, according to the winner of the 2019 Nobel Prize in Physiology or Medicine, Professor Sir Peter Ratcliffe.
Oct 23, 2020
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Researchers at The Wistar Institute and collaborators from the University of Notre Dame are developing anticancer compounds targeting a pathway of the endoplasmic reticulum (ER) stress response implicated in the development ...
Oct 13, 2020
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A new study led by scientists at VCU Massey Cancer Center has shown that an experimental drug known as AZ32 selectively sensitizes brain tumors to radiation and significantly extends the survival of mouse models with human ...
Jun 27, 2018
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Researchers have discovered a new class of drug that has the potential to help cancer patients who no longer respond to existing therapies.
Apr 10, 2018
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Researchers at Bellvitge Biomedical Research Institute have described a key cellular receptor in the processes of metastasis in ovarian cancer. The finding, published in Molecular Cancer Therapeutics, might lead to the use ...
Jan 5, 2018
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Researchers at the University of Cincinnati (UC) College of Medicine have shown that a new targeted treatment could benefit patients with certain pancreatic tumors by preventing spread of the cancer and protecting their heart ...
Dec 1, 2017
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More than 20 years after scientists revealed that mutations in the BRCA1 gene predispose women to breast cancer, Yale scientists have pinpointed the molecular mechanism that allows those mutations to wreak their havoc.
Oct 4, 2017
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Breaks in DNA can cause chromosome rearrangements, abnormalities linked to cancer. Now Yale scientists have identified how the molecule DNA2 helps begin the complex process of repairing these breaks.
Mar 24, 2017
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