A recent study published in Molecular Psychiatry has identified previously unknown alterations in neural connectivity that promote psychomotor disturbance—a slowing or reduction in movement—in individuals with major depressive ...
Jan 11, 2024
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Spinal muscular atrophy (SMA) is a devastating pediatric neuromuscular disorder caused by loss-of-function mutations in the SMN1 gene, which prevents the body from producing enough of the survival motor neuron (SMN) protein ...
Dec 7, 2023
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Modulating the activity of a kinase in motor neurons may help mitigate mitochondrial defects and other symptoms of spinal muscular atrophy, offering a new therapeutic avenue for the devastating disease, according to a Northwestern ...
Dec 5, 2023
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Hand tremors and slowed movements are two of the most widely recognized hallmarks of Parkinson's disease, and for many sufferers the first indication that something is amiss. But by the time these symptoms manifest, those ...
Jul 5, 2023
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For the first time ever, a molecule able to prevent the invasion of blood cells by parasites of the genus Plasmodium, responsible for malaria, has been identified and described by CNRS scientists, in collaboration with American ...
Jun 16, 2023
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My name is Antonio and I suffer from spinal muscular atrophy (SMA, for friends). My life expectancy was only a few years when I was born, almost half a century ago. And all because I "got" a rare, neurodegenerative disease, ...
Jun 15, 2023
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Motor neurons in healthy individuals send signals to the skeletal muscles. ALS, however, is currently an incurable, neurodegenerative disease in which motor neurons are severely damaged and can therefore no longer transmit ...
Jun 12, 2023
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A new study led by researchers at Brown University's Carney Institute for Brain Science offers a blueprint to help scientists prevent and reverse motor deficits that occur in old age.
May 11, 2023
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In virtually all persons with amyotrophic lateral sclerosis (ALS) and in up to half of all cases of Alzheimer's disease (AD) and frontotemporal dementia, a protein called TDP-43 is lost from its normal location in the nucleus ...
Mar 16, 2023
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A promising therapy for a range of brain diseases involves antisense oligonucleotides (ASOs)—specialized molecules that can modulate RNA and alter protein production—directly injected into the cerebrospinal fluid, in ...
Mar 13, 2023
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