A research team led by Professor Haruhisa Inoue of CiRA and Professor Hiroshi Nagashima of Meiji University has created a new porcine ALS model by introducing the human superoxide dismutase 1 (SOD1) gene with a mutation associated ...
Jan 13, 2023
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A new research paper was published in Aging, entitled, "Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs."
Jan 12, 2023
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Nerve cells need a lot of energy and oxygen. They receive both through the blood. This is why nerve tissue is usually crisscrossed by a large number of blood vessels. But what prevents neurons and vascular cells from getting ...
Dec 21, 2022
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A probiotic bacterium called Lacticaseibacillus rhamnosus HA-114 prevents neurodegeneration in the C. elegans worm, an animal model used to study amyotrophic lateral sclerosis (ALS).
Dec 20, 2022
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To perform coordinated movements, we rely on special sensory neurons in our muscles and joints. Without them, the brain wouldn't know what the rest of our body was doing. A team led by Niccolò Zampieri has studied their ...
Dec 9, 2022
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Researchers at Nagoya University in Japan have identified a novel genetic variant found in some patients with amyotrophic lateral sclerosis (ALS). Employing human-induced pluripotent stem (iPS) cells, they detailed the process ...
Dec 7, 2022
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Adopting some of the strategies behind successfully treating the childhood disease spinal muscular atrophy may enable development of therapies to curb the muscle decline that accompanies aging, new research suggests.
Nov 15, 2022
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When neurons involved in movement—called motor neurons—form, they must build connections that reach from the brain, brainstem, or spinal cord all the way to the head, arms, or the tips of the toes. How neurons navigate ...
Nov 3, 2022
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When humans and other mammals perform voluntary movements, a series of neural processes take place. The cerebral cortex, the outer region of the brain, sends signals to motor units (i.e., neurons) in the spinal cord, which ...
The Food and Drug Administration (FDA) recently approved the first new medication for ALS (amyotrophic lateral sclerosis) in five years—despite uncertainty about how much it helps patients with the progressive and devastating ...
Oct 18, 2022
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