Spinal muscular atrophy (SMA) is a devastating pediatric neuromuscular disorder caused by loss-of-function mutations in the SMN1 gene, which prevents the body from producing enough of the survival motor neuron (SMN) protein ...
Dec 7, 2023
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Modulating the activity of a kinase in motor neurons may help mitigate mitochondrial defects and other symptoms of spinal muscular atrophy, offering a new therapeutic avenue for the devastating disease, according to a Northwestern ...
Dec 5, 2023
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Neurosurgical treatment with deep brain stimulation in a relatively new target area has been shown to relieve involuntary tremors in Parkinson's disease and Essential Tremor for up to at least five and 10 years after treatment ...
Dec 4, 2023
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A new study, published in Cell Reports, reports a novel mechanism behind dysregulated neuronal activity, a key pathology of amyotrophic lateral sclerosis (ALS). Researchers at King's College London found that molecular, structural, ...
Nov 30, 2023
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Optimal windows exist for action and perception during the 0.8 seconds of a heartbeat, according to research published in the open-access journal PLOS Biology. The sequence of contraction and relaxation is linked to changes ...
Nov 28, 2023
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In a Nature Metabolism paper, researchers from the University of Pittsburgh detail a potential new target and a small-molecule drug candidate for treating Barth syndrome, a rare, life-threatening and currently incurable genetic ...
Nov 24, 2023
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The disease 5q-spinal muscular atrophy (5q-SMA) is one of the more common types of spinal muscular atrophy (SMA) affecting around 1 in 10,000 individuals worldwide. Currently, tests are unable to detect all pathogenic genetic ...
Nov 15, 2023
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Scientists at the Technical University of Munich (TUM) in cooperation with partner companies have developed a device to provide back muscle training. With the GyroTrainer, back strengthening exercises are adapted to the strength ...
Nov 14, 2023
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A pair of studies from the laboratory of Evangelos Kiskinis, Ph.D., associate professor in the Ken and Ruth Davee Department of Neurology's Division of Neuromuscular Disease and of Neuroscience, have uncovered novel cellular ...
Nov 14, 2023
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A research collaboration led by the University of Chinese Academy of Sciences, China, investigated the role of CHIT1, a protein associated with microglia, in aging.
