News tagged with mutant cells
Study uncovers mechanism by which tumor suppressor MIG6 triggers cell suicide
Death plays a big role in keeping things alive. Consider the tightly orchestrated suicide of cells—a phenomenon essential to everything from shaping an embryo to keeping it free of cancer later in life. ...
Cancer
Sep 24, 2012 |
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Study shows vitamin E may decrease cancer risk in Cowden syndrome patients
Cleveland Clinic researchers have discovered that vitamin E may prevent cancer in patients with an under-recognized genetic disorder.
Cancer
Sep 17, 2012 |
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Toxic protein build-up in blood shines light on Huntington's disease
A new light-based technique for measuring levels of the toxic protein that causes Huntington's disease (HD) has been used to demonstrate that the protein builds up gradually in blood cells. Published today ...
Neuroscience
Sep 17, 2012 |
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Researchers solve mystery surrounding the death of two sisters nearly 50 years ago
Researchers at Mount Sinai School of Medicine have identified the genetic cause of a rare and fatal bone disease by studying frozen skin cells that were taken from a child with the condition almost fifty years ago. Their ...
Genetics
Aug 29, 2012 |
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Enlisting the AIDS virus to fight cancer
(Medical Xpress)—Can HIV be transformed into a biotechnological tool for improving human health? According to a CNRS team at the Architecture et Réactivité de l'ARN (RNA Architecture and Reactivity) laboratory, ...
Genetics
Aug 29, 2012 |
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Possible muscle disease therapeutic target found
The study of muscular system protein myostatin has been of great interest to researchers as a potential therapeutic target for people with muscular disorders. Although much is known about how myostatin affects muscle growth, ...
Medical research
Aug 06, 2012 |
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Uncommon BRAF mutation in melanoma sensitive to MEK inhibitor drug therapy
An uncommon mutation of the BRAF gene in melanoma patients has been found to respond to MEK inhibitor drugs, providing a rationale for routine screening and therapy in melanoma patients who harbor the BRAF L597 mutation.
Cancer
Jul 16, 2012 |
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A new target in acute myeloid leukemia
Acute myeloid leukemia, a common leukemia in adults, is characterized by aberrant proliferation of cancerous bone marrow cells. Activating mutations in a protein receptor known as FLT3 receptor are among the most prevalent ...
Cancer
Jul 16, 2012 |
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New mouse model helps explain gene discovery in congenital heart disease
Scientists now have clues to how a gene mutation discovered in families affected with congenital heart disease leads to underdevelopment of the walls that separate the heart into four chambers. A Nationwide Children's Hospital ...
Genetics
Jun 26, 2012 |
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Fruit flies with Restless Legs Syndrome point to a genetic cause
When flies are made to lose a gene with links to Restless Legs Syndrome (RLS), they suffer the same sleep disturbances and restlessness that human patients do. The findings reported online on May 31 in Current Biology strong ...
Genetics
May 31, 2012 |
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Mice with big brains provide insight into brain regeneration and developmental disorders
Scientists at the Ottawa Hospital Research Institute (OHRI) and the University of Ottawa (uOttawa) have discovered that mice that lack a gene called Snf2l have brains that are 35 per cent larger than normal. ...
Genetics
May 15, 2012 |
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New advances in treating inherited retinal diseases highlighted in Human Gene Therapy
Gene therapy strategies to prevent and treat inherited diseases of the retina that can cause blindness have progressed rapidly. Positive results in animal models of human retinal disease continue to emerge, ...
Genetics
May 08, 2012 |
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KRAS gene mutation and amplification status affects sensitivity to antifolate therapy
Testing patients with non-small cell lung cancer for both mutations and amplifications of the KRAS gene prior to therapy may help to predict response to treatment with antifolates, according to the updated results of a preclinical ...
Cancer
Apr 04, 2012 |
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New research could provide roadmap for more effective drug discovery for cystic fibrosis
A recent study led by Gergely Lukacs, a professor at McGill University's Faculty of Medicine, Department of Physiology, and published in the January issue of Cell, has shown that restoring normal function to the mutant gene p ...
Medical research
Mar 12, 2012 |
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Deeper view of HIV reveals impact of early mutations
Mutations in HIV that develop during the first few weeks of infection may play a critical role in undermining a successful early immune response, a finding that reveals the importance of vaccines targeting regions of the ...
HIV & AIDS
Mar 08, 2012 |
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