News tagged with neurotoxicity
Neurotoxicity occurs when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system in such a way as to cause damage to nervous tissue. This can eventually disrupt or even kill neurons, key cells that transmit and process signals in the brain and other parts of the nervous system. Neurotoxicity can result from exposure to substances used in chemotherapy, radiation treatment, drug therapies, certain drug abuse, and organ transplants, as well as exposure to heavy metals, certain foods and food additives, pesticides, industrial and/or cleaning solvents, cosmetics, and some naturally occurring substances. Symptoms may appear immediately after exposure or be delayed. They may include limb weakness or numbness, loss of memory, vision, and/or intellect, uncontrollable obsessive and/or compulsive behaviors, delusions, headache, cognitive and behavioral problems and sexual dysfunction. Individuals with certain disorders may be especially vulnerable to neurotoxins.
The name implies the role of a neurotoxin although the term 'neurotoxic' may be used more loosely to describe states that are known to cause physical brain damage but where no obvious neurotoxin has been identified.
The term neurotoxic is used to describe a substance, condition or state that damages the nervous system and/or brain, usually by killing neurons. The term is generally used to describe a condition or substance that has been shown to result in observable physical damage. The presence of neurocognitive deficits alone is not usually considered sufficient evidence of neurotoxicity, as many substances exist which may impair neurocognitive performance without resulting in the death of neurons. This may be due to the direct action of the substance, with the impairment and neurocognitive deficits being temporary, and resolving when the substance is metabolised from the body. In some cases the level or exposure-time may be critical, with some substances only becoming neurotoxic in certain doses or time periods. Some of the most common naturally occurring brain toxins that lead to neurotoxicity as a result of excessive dosage are: Beta amyloid (Aβ), Glutamate and Oxygen radicals. When present in high concentrations they can lead to neurotoxicity and death (apoptosis). Some of the symptoms that result from cell death include: loss of motor control, cognitive deterioration and autonomic nervous system dysfunction. Additionally, neurotoxicity has been found to be a major cause of neurodegenerative diseases such as Alzheimer’s disease (AD).
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
(HealthDay)—Patients with Cushing's syndrome have abnormal brain metabolites suggestive of neuronal dysfunction even after they appeared to have been cured, according to a study presented at the annual ...
Diseases, Conditions, Syndromes May 03, 2013 | not rated yet | 0
Silvery, ductile, malleable and so very, very useful, aluminium is the most common metal in the Earth's crust. But despite its importance (or perhaps because of it), there are fears that this metal causes ...
Health Apr 01, 2013 | 4.8 / 5 (4) | 0
An iron imbalance caused by prion proteins collecting in the brain is a likely cause of cell death in Creutzfeldt-Jakob disease (CJD), researchers at Case Western Reserve University School of Medicine have found.
Alzheimer's disease & dementia Mar 13, 2013 | 5 / 5 (2) | 0 |
Scientists have used the venom of Africa's lethal black mamba to produce a surprising outcome in mice which they hope to replicate in humans—effective pain relief without toxic side effects.
Medical research Oct 03, 2012 | 5 / 5 (5) | 0
An agent under consideration for use in PET imaging combats neuronal death to relieve Parkinsonian symptoms in animal models, according to a study published on April 2nd in the Journal of Experimental Medicine.
Parkinson's & Movement disorders Apr 02, 2012 | 5 / 5 (2) | 0
(Medical Xpress) -- A three-drug combination treatment for the blood cancer multiple myeloma compares favorably to the best established therapy for newly diagnosed patients, according to a multi-center study led by Andrzej ...
Cancer Dec 08, 2011 | not rated yet | 0
A University of Kentucky faculty member is a contributing author on a new study demonstrating a connection between a common solvent chemical and Parkinson's disease. Dr. Franca Cambi of the UK Kentucky Neuroscience Institute ...
Parkinson's & Movement disorders Nov 29, 2011 | not rated yet | 0 |
Nicolas G. Bazan, MD, Ph.D, Boyd Professor and Director of the Neuroscience Center of Excellence at LSU Health Sciences Center New Orleans, and David Stark, an MD/Ph.D student working in his lab, have discovered how a key ...
Neuroscience Sep 28, 2011 | not rated yet | 0
Binge drinking is prevalent among university students, especially in the United States. One brain structure particularly sensitive to alcohol's neurotoxicity during development is the hippocampus, which plays a key role ...
Health May 16, 2011 | 3 / 5 (2) | 0