Immunology

A unique window into 'original antigenic sin'

Our immune systems react most strongly to the viral strains we encountered in our childhoods. Scientists call this original antigenic sin (OAS)—the body's first blush with a virus like influenza or COVID being the "original ...

HIV & AIDS

Experimental mRNA HIV vaccine safe, shows promise in animals

An experimental HIV vaccine based on mRNA—the same platform technology used in two highly effective COVID-19 vaccines—shows promise in mice and non-human primates, according to scientists at the National Institute of ...

Diseases, Conditions, Syndromes

mRNA vaccine yields full protection against malaria in mice

Scientists from the Walter Reed Army Institute of Research and Naval Medical Research Center partnered with researchers at the University of Pennsylvania and Acuitas Therapeutics to develop a novel vaccine based on mRNA technology ...

Diseases, Conditions, Syndromes

Will the COVID-19 vaccine work as well in patients with obesity?

When researchers began to develop what they hoped would be an effective COVID-19 vaccine, they already knew that H1N1 influenza—a novel virus, like COVID-19 – more severely affected patients with overweight or obesity. ...

Diseases, Conditions, Syndromes

Testing tuberculosis vaccine combinations for COVID-19

Researchers at the University of Sydney and Centenary Institute are repurposing an existing tuberculosis vaccine to see if it can be used in a new way against COVID-19 to develop a novel vaccine.

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