Researchers at Dana-Farber Cancer Institute have shown that advanced pancreatic cancers in mice can't survive without continued expression of a mutant oncogene that "rewires" key metabolic pathways to fuel the cancer cells.
Apr 26, 2012
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Exon 20 insertions are the third most common family of epidermal growth factor receptor (EGFR) mutations found in non–small-cell lung cancer (NSCLC). Little is known about cancers harboring these mutations aside from their ...
Jan 15, 2013
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An interdisciplinary team of chemists, oncologists and one statistician at Stanford has taken the first step toward developing a technique that can identify the origin of certain types of cancer—a potential boon to doctors ...
Jul 11, 2014
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Northwestern Medicine investigators have discovered the epigenetic mechanisms involved in the regulation of multiple oncogenes in glioma cells, mechanisms that promote overall glioma tumor growth and resistance to therapy, ...
Aug 26, 2021
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Blocking dietary sugar and its activity in tumor cells may reduce cancer risk and progression, according to researchers from the Icahn School of Medicine. The study, conducted in fruit flies and published in the journal Cell, ...
Aug 1, 2013
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A typical cancer cell has thousands of mutations scattered throughout its genome and hundreds of mutated genes. However, only a handful of those genes, known as drivers, are responsible for cancerous traits such as uncontrolled ...
Feb 4, 2013
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As a rare and lethal liver cancer that disproportionately harms young adults, fibrolamellar carcinoma is nearly incurable. Surgery can remove the tumor, but no existing therapies are capable of reining in the cancer once ...
Nov 10, 2022
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Viruses prompt oncogenic transformation by genetically altering infected cells. Several recent studies have demonstrated that viruses alter the expression of microRNAs, non-coding RNA molecules that can block the expression ...
Jan 16, 2013
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Researchers led by a team at the University of Illinois at Chicago, have identified a novel role for a signaling mechanism in lung cells that permanently places them into a state of suspended animation called senescence. ...
Mar 2, 2015
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A new study describes a therapeutic approach to halting cancer progression by exploiting a previously unrecognized "addiction" of leukemia cells to specific signaling molecules. The research, published by Cell Press online ...
Apr 16, 2012
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