Peptide based drug candidates are being discovered at an increasingly rapid pace as therapeutics for many diseases and pain management. . For decades the opioid receptors have been an attractive therapeutic target for pain ...
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Infertility has become a major medical and social problem worldwide and due in part to male infertility. Yet the molecular mechanisms involved in spermatogenesis are only now beginning to emerge. A piece of research led by ...
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In a multicenter, randomized clinical trial, ex-prisoners who received six monthly injections of naltrexone—a long-acting medication that blocks opioid receptors in the brain—were significantly less likely to resume opioid ...
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University of North Carolina researchers uncovered a cellular mechanism by which kappa opioid receptors (KOR) drive anxiety. These proteins inhibit the release of the neurotransmitter glutamate in a part of the brain that ...
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Currently available evidence from randomized controlled trials (RCT) does not support the use of nalmefene for harm reduction for people with alcohol dependence, according to a systematic review and meta-analysis (SRMA) published ...
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Researchers at Aalto University and University of Turku have revealed how obesity surgery recovers opioid neurotransmission in the brain.
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If you have an itch, you have to scratch it. But that's a problem for people with a condition called "chronic intractable itch," where that itchy sensation never goes away—a difficult-to-treat condition closely associated ...
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A*STAR researchers have found that specialized skin receptors associated with sensing pain also loosen the bonds between cells in skin wounds, enhancing the cells' ability to move into the wound and accelerate the healing ...
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Once used in the 18th century as currency to reverse the trade imbalance between China and Britain, morphine and its pain-killing qualities have been misunderstood (and misused) almost continually ever since.
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New research may help explain why drug treatments for addiction and depression don't work for some patients.
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