News tagged with osteoclasts

Mechanical stimuli control bone development

Researchers from ETH Zurich have successfully demonstrated, for the first time in vivo, how bone tissue responds to local mechanical stimuli that control bone formation. The study reveals how important it is ...

Sep 02, 2013
popularity 4 / 5 (1) | comments 0 | with audio podcast

Emerging cancer drugs may drive bone tumors

Cancer drugs should kill tumors, not encourage their spread. But new evidence suggests that an otherwise promising class of drugs may actually increase the risk of tumors spreading to bone, according to researchers ...

Feb 13, 2013
popularity not rated yet | comments 0 | with audio podcast

Osteoclast

An osteoclast (from the Greek words for "bone" (Οστό) and "broken" (κλαστός)) is a type of bone cell that removes bone tissue by removing its mineralized matrix and breaking up the organic bone (organic dry weight is 90% collagen). This process is known as bone resorption. Osteoclasts were discovered by Kolliker in 1873. Osteoclasts and osteoblasts are instrumental in controlling the amount of bone tissue: osteoblasts form bone, osteoclasts resorb bone. Osteoclasts are formed by the fusion of cells of the monocyte-macrophage cell line. Osteoclasts are characterized by high expression of tartrate resistant acid phosphatase (TRAP) and cathepsin K.

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