News tagged with osteoclasts
Osteoclast
An osteoclast (from the Greek words for "bone" (Οστό) and "broken" (κλαστός)) is a type of bone cell that removes bone tissue by removing its mineralized matrix and breaking up the organic bone (organic dry weight is 90% collagen). This process is known as bone resorption. Osteoclasts were discovered by Kolliker in 1873. Osteoclasts and osteoblasts are instrumental in controlling the amount of bone tissue: osteoblasts form bone, osteoclasts resorb bone. Osteoclasts are formed by the fusion of cells of the monocyte-macrophage cell line. Osteoclasts are characterized by high expression of tartrate resistant acid phosphatase (TRAP) and cathepsin K.
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Fusion and cell death in the development of skeletal muscle
(Medical Xpress)—Membrane fusion is a highly regulated event, both inside cells, and between them. From the moment a sperm first fuses with an egg, subsequent developmental events depend upon its proper ...
Medical research
Apr 26, 2013 |
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New osteoporosis drug combination outperforms current alternatives
A combination of two FDA-approved osteoporosis drugs with different mechanisms of action was found to increase bone density better than treatment with either drug alone in a small clinical trial. As reported in paper receiving ...
Diseases, Conditions, Syndromes
May 14, 2013 |
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Emerging cancer drugs may drive bone tumors
Cancer drugs should kill tumors, not encourage their spread. But new evidence suggests that an otherwise promising class of drugs may actually increase the risk of tumors spreading to bone, according to researchers ...
Cancer
Feb 13, 2013 |
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Researchers use blood testing to predict level of enzymes that facilitate disease progression
Predicting how atherosclerosis, osteoporosis or cancer will progress or respond to drugs in individual patients is difficult. In a new study, researchers took another step toward that goal by developing a ...
Medical research
Nov 01, 2012 |
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When bone-eating cells gain the upper hand
Advanced osteoporosis is often the most severe sequela, or resulting condition, of plasma cell cancer (multiple myeloma). Abnormally functioning stem cells are a key causal factor.
Medical research
Mar 11, 2013 |
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Drugs reduce bone cancer damage but clinical guidance remains non-specific
Bone cancer-related fractures and pain can be reduced by drug treatment, but no one drug is superior, according to a review published in The Cochrane Library. Researchers undertook a systematic review of the current eviden ...
Cancer
May 15, 2012 |
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