Understanding of the mechanisms of drug resistance to dual-agent chemotherapy in ovarian cancer
More than half of all patients with ovarian cancer experience recurrent disease and will eventually fail to respond to chemotherapy. The failure of chemotherapy is usually due to the development of resistance to the two main ...
Cancer
Nov 29, 2012 |
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MicroRNAs can convert normal cells into cancer promoters
Unraveling the mechanism that ovarian cancer cells use to change normal cells around them into cells that promote tumor growth has identified several new targets for treatment of this deadly disease.
Cancer
Nov 21, 2012 |
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New mechanism of action for PARP inhibitors discovered
New understanding of how drugs called PARP inhibitors, which have already shown promise for the treatment of women with familial breast and ovarian cancers linked to BRCA mutations, exert their anticancer effects has led ...
Cancer
Nov 09, 2012 |
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UNM Cancer Center researcher looks for genetic markers for ovarian cancer
Ovarian cancer is a deadly disease. With no overt symptoms and no screening tests to catch it early, ovarian cancer is often detected at stage 3 or later. By then, it can be very aggressive and may have spread beyond the ...
Cancer
Oct 23, 2012 |
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Researchers reveal how Trop2 protein drives tumor growth in prostate, other epithelial cancers
(Medical Xpress)—Researchers led by Tanya Stoyanova and Dr. Owen Witte of UCLA's Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have determined how a protein known as Trop2 drives the growth ...
Cancer
Oct 16, 2012 |
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Blood cells may offer telltale clues in cancer diagnosis
Postdoctoral Research Fellow Devin Koestler is a biostatistician in the Geisel School of Medicine at Dartmouth. He develops and applies statistical methods to large volumes of data, seeking new approaches ...
Cancer
Oct 12, 2012 |
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Squeezing ovarian cancer cells to predict metastatic potential
(Medical Xpress)—New Georgia Tech research shows that cell stiffness could be a valuable clue for doctors as they search for and treat cancerous cells before they're able to spread. The findings, which ...
Cancer
Oct 10, 2012 |
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Ovarian cancer stem cells targeted in new research
Ovarian cancer takes the lives of nearly 900 Australian women each year. It's called the silent killer because by the time most cases are detected, the cancer has spread to other vital organs throughout the abdominal area.
Cancer
Oct 05, 2012 |
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New type of drug leads to hope against resistant ovarian cancer
Scientists at USC have discovered a new type of drug for the treatment of ovarian cancer that works in a way that should not only decrease the number of doses that patients need to take, but also may make it effective for ...
Cancer
Oct 03, 2012 |
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An old drug finds a new use
Dr. Anglea Wandinger-Ness and Dr. Laurie Hudson were awarded a Provocative Questions grant to investigate the use of R-ketorolac against ovarian cancer. Ketorolac is an NSAID that the FDA approved for human use in 1991. They ...
Medications
Sep 27, 2012 |
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Researchers find possible key to regulation of ovarian cancer stem cells
(Medical Xpress)—Researchers at Moffitt Cancer Center have discovered that the micro ribonucleic acid miR-214 plays a critical role in regulating ovarian cancer stem cell properties. This knowledge, said the researchers, ...
Cancer
Sep 27, 2012 |
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Treating ovarian cancer: New pathways through genetics
A new discovery that sheds light on the genetic make up of ovarian cancer cells could explain why some women survive longer than others with this deadly disease. A multi-disciplinary team led by the Research Institute of ...
Cancer
Sep 24, 2012 |
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BRCA1 or BRCA2 mutation research may offer treatment option to certain patients
(Medical Xpress)—Ongoing research at the Methodist Cancer Center could reveal whether metastatic breast cancer patients with BRCA gene mutations are particularly responsive to a drug regimen that includes Veliparib, an ...
Cancer
Sep 20, 2012 |
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Gene helps predict which ovarian cancer sufferers will benefit most from chemotherapy
(Medical Xpress)—Researchers from the University of Dundee have discovered that measuring how active a gene is could predict which women with ovarian cancer will benefit from platinum-based chemotherapy ...
Cancer
Sep 19, 2012 |
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PARP inhibitors may have clinical utility in HER2-positive breast cancers
Poly (ADP-Ribose) polymerase (PARP) inhibitors, shown to have clinical activity when used alone in women with familial breast and ovarian cancers linked to BRCA mutations, may be a novel treatment strategy in women with HER2-positive ...
Cancer
Sep 17, 2012 |
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