Cardiology

Newly discovered mechanism regulates myocardial distensibility

A healthy heart beats 50 to 100 times a minute and pumps 8,000 liters of blood around our body every day. A precondition for this function is the elasticity of the cardiac walls, which dilate as blood flows in (diastole) ...

Immunology

Toxic cell atlas guides new therapies for neurodegeneration

A common thread in many inflammatory and neurodegenerative diseases, including multiple sclerosis (MS), is damage caused by oxidative stress. Oxidative stress occurs when cells produce toxic substances known as reactive oxygen ...

Medical research

Life's constant struggle against ferroptosis

In the natural course of events, multicellular organisms frequently need to eliminate cells. In humans, for example, superfluous tails, finger webbing, immune cells raised with wrongthink or neurons making inappropriate friends ...

Medical research

Adult fly intestine could help understand intestinal regeneration

Intestinal epithelial cells (IECs) are exposed to diverse types of environmental stresses such as bacteria and toxins, but the mechanisms by which epithelial cells sense stress are not well understood. New research by the ...

Medical research

Runaway mitochondria cause telomere damage in cells

Researchers at UPMC Hillman Cancer Center provide the first concrete evidence for the long-held belief that sick mitochondria pollute the cells they're supposed to be supplying with power.

Oncology & Cancer

Cancer cell's 'self eating' tactic may be its weakness

Cancer cells use a bizarre strategy to reproduce in a tumor's low-energy environment; they mutilate their own mitochondria! Researchers at Cold Spring Harbor Laboratory (CSHL) also know how this occurs, offering a promising ...

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