News tagged with p53 mutations
Wip1 could be new target for cancer treatment
Researchers have uncovered mutations in the phosphatase Wip1 that enable cancer cells to foil the tumor suppressor p53, according to a study in The Journal of Cell Biology. The results could provide a new ...
Cancer
May 06, 2013 |
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Deficiency in p53 anti-tumor protein delays DNA repair after radiation
Researchers at Moffitt Cancer Center have found that a deficiency in an important anti-tumor protein, p53, can slow or delay DNA repair after radiation treatment. They suggest that this is because p53 regulates the expression ...
Cancer
Apr 23, 2013 |
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Study finds key to calling back-up help when tumor-fighter p53 goes down
Tumor suppression, the family business of the sibling genes p53, p63 and p73, is undermined from within by the split personalities of p63 and p73, which each produce protein forms that not only block the work of the other ...
Cancer
Apr 08, 2013 |
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Dietary glucose affects the levels of a powerful oncogene in mice
An animal study conducted by researchers at Georgetown Lombardi Comprehensive Cancer Center raises questions about the consequences of diet—specifically glucose, the plant-based sugar that fuels cell life—on increased ...
Cancer
Nov 15, 2012 |
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Prions and cancer: A story unfolding
Prions, the causal agents of Mad Cow and other diseases, are very unique infectious particles. They are proteins in which the complex molecular three-dimensional folding process just went astray. For reasons not yet understood, ...
Cancer
Jun 25, 2012 |
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Scientists find new role for P53 genetic mutation -- initiation of prostate cancer
A team of UC Davis investigators has found that a genetic mutation may play an important role in the development of prostate cancer. The mutation of the so-called p53 (or Tp53) gene was previously implicated in late disease ...
Cancer
Jun 07, 2012 |
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Elimination of two ribosome subunits activates cell cycle control
Alterations in the formation of ribosomes (the elements of the cell where proteins are made) cause the induction of p53 protein and cell cycle disruption. This process is crucial to understand fundamental biological processes ...
Genetics
May 22, 2012 |
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Drug kills cancer cells by restoring faulty tumor suppressor
A new study describes a compound that selectively kills cancer cells by restoring the structure and function of one of the most commonly mutated proteins in human cancer, the "tumor suppressor" p53. The research, published ...
Cancer
May 14, 2012 |
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DGK-alpha helps cancer cells gain traction and mobilize
Metastasizing cancer cells often express integrins that provide better traction. A new study in The Journal of Cell Biology reveals how a lipid-converting enzyme helps the cells mobilize these integrins.
Cancer
Jan 23, 2012 |
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Gene found to play role in early cancer
(Medical Xpress) -- Mutations to a gene called p53 have been linked to half of all cancers, leading to tumor growth and the spread of cancerous cells. Now, a Cornell-led study identifies for the first time the mechanisms ...
Cancer
Aug 24, 2011 |
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Cancer cells and stem cells share same origin: study
Oncogenes are generally thought to be genes that, when mutated, change healthy cells into cancerous tumor cells. Scientists at the Keck School of Medicine of the University of Southern California (USC) have proven that those ...
Cancer
Jul 18, 2011 |
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Gene fault could predict ovarian cancer drug success
Faults in a gene commonly inactivated in many different types of cancer could be used to predict which drug combination ovarian cancer patients are most likely to benefit from, according to research at Newcastle University.
Cancer
Jun 06, 2011 |
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