Researchers at Moffitt Cancer Center have found that a deficiency in an important anti-tumor protein, p53, can slow or delay DNA repair after radiation treatment. They suggest that this is because p53 regulates the expression ...
Apr 23, 2013
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Tumor suppression, the family business of the sibling genes p53, p63 and p73, is undermined from within by the split personalities of p63 and p73, which each produce protein forms that not only block the work of the other ...
Apr 8, 2013
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An animal study conducted by researchers at Georgetown Lombardi Comprehensive Cancer Center raises questions about the consequences of diet—specifically glucose, the plant-based sugar that fuels cell life—on increased ...
Nov 15, 2012
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Prions, the causal agents of Mad Cow and other diseases, are very unique infectious particles. They are proteins in which the complex molecular three-dimensional folding process just went astray. For reasons not yet understood, ...
Jun 25, 2012
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A team of UC Davis investigators has found that a genetic mutation may play an important role in the development of prostate cancer. The mutation of the so-called p53 (or Tp53) gene was previously implicated in late disease ...
Jun 7, 2012
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Alterations in the formation of ribosomes (the elements of the cell where proteins are made) cause the induction of p53 protein and cell cycle disruption. This process is crucial to understand fundamental biological processes ...
May 22, 2012
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A new study describes a compound that selectively kills cancer cells by restoring the structure and function of one of the most commonly mutated proteins in human cancer, the "tumor suppressor" p53. The research, published ...
May 14, 2012
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Metastasizing cancer cells often express integrins that provide better traction. A new study in The Journal of Cell Biology reveals how a lipid-converting enzyme helps the cells mobilize these integrins.
Jan 23, 2012
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(Medical Xpress) -- Mutations to a gene called p53 have been linked to half of all cancers, leading to tumor growth and the spread of cancerous cells. Now, a Cornell-led study identifies for the first time the mechanisms ...
Aug 24, 2011
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Oncogenes are generally thought to be genes that, when mutated, change healthy cells into cancerous tumor cells. Scientists at the Keck School of Medicine of the University of Southern California (USC) have proven that those ...
Jul 18, 2011
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