News tagged with p53
New drug enhances radiation treatment for brain cancer in preclinical studies
A novel drug may help increase the effectiveness of radiation therapy for the most deadly form of brain cancer, report scientists at Virginia Commonwealth University Massey Cancer Center. In mouse models of human glioblastoma ...
Cancer
May 14, 2013 |
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Research reveals cancer-suppressing protein 'multitasks'
The understanding of how a powerful protein called p53 protects against cancer development has been upended by a discovery by Walter and Eliza Hall Institute researchers.
Cancer
May 09, 2013 |
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Wip1 could be new target for cancer treatment
Researchers have uncovered mutations in the phosphatase Wip1 that enable cancer cells to foil the tumor suppressor p53, according to a study in The Journal of Cell Biology. The results could provide a new ...
Cancer
May 06, 2013 |
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Protein complex may play role in preventing many forms of cancer, study shows
Researchers at the Stanford University School of Medicine have identified a group of proteins that are mutated in about one-fifth of all human cancers. The finding suggests that the proteins, which are members of a protein ...
Genetics
May 05, 2013 |
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New study reveals how tumor suppressor p53 shut down in metastatic melanoma
Cancer cells are a problem for the body because they multiply recklessly, refuse to die and blithely metastasize to set up shop in places where they don't belong. One protein that keeps healthy cells from behaving this way ...
Cancer
Apr 25, 2013 |
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Deficiency in p53 anti-tumor protein delays DNA repair after radiation
Researchers at Moffitt Cancer Center have found that a deficiency in an important anti-tumor protein, p53, can slow or delay DNA repair after radiation treatment. They suggest that this is because p53 regulates the expression ...
Cancer
Apr 23, 2013 |
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Study discovers that stem cell senescence drives aging
Declining levels of the protein BubR1 occur when both people and animals age, and contribute to cell senescence or deterioration, weight loss, muscle wasting and cataracts. Mayo Clinic researchers have shown that adult progenitor ...
Medical research
Apr 18, 2013 |
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Cancer cell metabolism kills
Adenosine-5'-triphosphate (ATP) is the main energy source for all forms of work inside our cells. Scientists from the University of Helsinki, Finland, have found that even a short-term shortage of ATP supply ...
Cancer
Apr 15, 2013 |
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Two-drug combo more effective in treating sarcomas, study shows
Researchers at Moffitt Cancer Center and colleagues at the University of South Florida have found that when given together, a two-drug combination acts synergistically in test animals modeled with sarcoma tumors. They report ...
Cancer
Apr 09, 2013 |
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Study finds key to calling back-up help when tumor-fighter p53 goes down
Tumor suppression, the family business of the sibling genes p53, p63 and p73, is undermined from within by the split personalities of p63 and p73, which each produce protein forms that not only block the work of the other ...
Cancer
Apr 08, 2013 |
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KDM1 may represent a new therapeutic target for glioma
Researchers have generated preclinical data demonstrating that the protein KDM1, which functions as a lysine demethylase, is a potential target for glioma treatment, according to Gangadhara R. Sareddy, Ph.D., a postdoctoral ...
Cancer
Apr 08, 2013 |
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Researchers find new way of killing leukaemia cells
(Medical Xpress)—Researchers at the University of Dundee have identified a new way of killing cancer cells in patients with a certain kind of leukaemia, which could lead to the development of safer anti-leukaemic drugs.
Cancer
Mar 04, 2013 |
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Protein that represses critical checkpoint protein for cellular growth helps drive tumor development
(Medical Xpress)—One of the hallmarks of cancer is unchecked cellular growth. Fortunately, our cells contain a number of tumor suppressor proteins, including the cell cycle regulator p21, to keep cell growth ...
Cancer
Feb 13, 2013 |
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New target for treating wide spectrum of cancers
(Medical Xpress)—UC Irvine biologists, chemists and computer scientists have identified an elusive pocket on the surface of the p53 protein that can be targeted by cancer-fighting drugs. The finding heralds a new treatment ...
Cancer
Jan 31, 2013 |
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Singapore scientists discover p53 mutation hinders cancer treatment response
Scientists from the National Cancer Centre Singapore (NCCS) have discovered the workings of the gene that has been hindering treatment response in cancer patients. This discovery was made after 5 years of studying the mutant ...
Cancer
Jan 25, 2013 |
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P53
More reference expression data
p53 (also known as protein 53 or tumor protein 53), is a transcription factor which in humans is encoded by the TP53 gene. p53 is important in multicellular organisms, where it regulates the cell cycle and thus functions as a tumor suppressor that is involved in preventing cancer. As such, p53 has been described as "the guardian of the genome," "the guardian angel gene," and the "master watchman," referring to its role in conserving stability by preventing genome mutation.
The name p53 is in reference to its apparent molecular mass: it runs as a 53 kilodalton (kDa) protein on SDS-PAGE. But based on calculations from its amino acid residues, p53's mass is actually only 43.7kDa. This difference is due to the high number of proline residues in the protein which slow its migration on SDS-PAGE, thus making it appear heavier than it actually is. This effect is observed with p53 from a variety of species, including humans, rodents, frogs, and fish.
For more information about P53, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
