Computer model helps researchers hunt out cancer-causing mutational signatures in the genome
(Medical Xpress)—Researchers from the Wellcome Trust Sanger Institute's cancer genome project have developed a computer model to identify the fingerprints of DNA-damaging processes that drive cancer development. ...
Genetics
Jan 11, 2013 |
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Sensory hair cells regenerated, hearing restored in mammal ear
Hearing loss is a significant public health problem affecting close to 50 million people in the United States alone. Sensorineural hearing loss is the most common form and is caused by the loss of sensory ...
Neuroscience
Jan 09, 2013 |
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Small peptide ameliorates autoimmune skin blistering disease in mice
Pemphigus vulgaris is a life-threatening autoimmune skin disease that is occurs when the body's immune system generates antibodies that target proteins in the skin known as desomogleins. Desmogleins help to form the adhesive ...
Immunology
Jan 09, 2013 |
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The pain puzzle: Uncovering how morphine increases pain in some people
For individuals with agonizing pain, it is a cruel blow when the gold-standard medication actually causes more pain. Adults and children whose pain gets worse when treated with morphine may be closer to a solution, based ...
Neuroscience
Jan 06, 2013 |
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Scientists find new molecule to target in pancreatic cancer treatment
Researchers at Mayo Clinic in Florida have identified a new target to improve treatment of pancreatic ductal adenocarcinoma cancer, which accounts for more than 95 percent of pancreatic cancer cases. This fast-growing, often ...
Cancer
Jan 03, 2013 |
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Scientists home in on cause of osteoarthritis pain
Researchers at Rush University Medical Center, in collaboration with researchers at Northwestern University, have identified a molecular mechanism central to the development of osteoarthritis (OA) pain, a finding that could ...
Arthritis & Rheumatism
Dec 27, 2012 |
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Scientists find mechanism that triggers immune responses to DNA
(Medical Xpress)—Free-floating pieces of DNA in a cell's watery interior can mean bad things: invading viruses, bacteria, or parasites, ruptured cellular membranes, or disease. Genetic material is meant to be contained ...
Medical research
Dec 21, 2012 |
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Mount Sinai grad student, 25, named to Forbes '30 Under 30' in Science and Healthcare
Jillian Shapiro, a third-year graduate student at the Icahn School of Medicine at Mount Sinai, has been named to the second annual Forbes "30 Under 30" list in "Science and Health." The honorees "reflect the way that the he ...
Medical research
Dec 20, 2012 |
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MicroRNAs present exciting opportunities for cancer therapy and diagnosis
As many as 50 percent of all human protein-coding genes are regulated by microRNA (miRNA) molecules. While some miRNAs impact onset and progression of cancer, others can actually suppress the development of malignant tumors ...
Cancer
Dec 19, 2012 |
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Ability to chart the molecular progress of diabetes brings personalized medicine closer to realization
Researchers in Singapore have succeeded in tracking, for the first time, the molecular changes caused by type 2 diabetes that affect how the body handles glucose production in the liver. In a series of experiments ...
Diabetes
Dec 19, 2012 |
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Study unravels biological pathway that controls the leakiness of blood vessels
(Medical Xpress)—A research team led by scientists at Mayo Clinic in Florida have decoded the entire pathway that regulates leakiness of blood vessels—a condition that promotes a wide number of disorders, such as heart ...
Medical research
Dec 17, 2012 |
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Two new genetic mutations associated with Cowden syndrome
Cleveland Clinic researchers from the Lerner Research Institute have uncovered two new genes associated with Cowden syndrome (CS) according to a new study, published today in the online version of the American Journal of ...
Genetics
Dec 13, 2012 |
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Research may have important implications for combating diabetes
(Medical Xpress)—Research by University of Notre Dame biochemist Anthony S. Serianni is providing new insights that could have important implications for understanding and treating diabetes.
Diabetes
Dec 11, 2012 |
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Novel drug therapy targets aggressive form of non-Hodgkin's lymphoma
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin's lymphoma and the seventh most frequently diagnosed cancer. The most chemotherapy resistant form of DLBCL, called activated B-cell – DLBCL ...
Cancer
Dec 10, 2012 |
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Scientists identify liposarcoma tumors that respond to chemotherapy
Liposarcoma, the most common type of sarcoma, is an often lethal form of cancer that develops in fat cells. It is particularly deadly, in part, because the tumors are not consistently visible with positron emission tomography ...
Cancer
Dec 10, 2012 |
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