News tagged with polymerase

A protein complex for the long haul

A multiprotein complex called TREX plays a key role in expression of the genetic information. Moreover, as a new study demonstrates – the longer the gene, the greater the need for TREX function.

Nov 18, 2013
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Association between virus, bladder cancers detected

A Lawrence Livermore National Laboratory (LLNL)-developed biological detection technology has been employed as part of an international collaboration that has detected a virus in bladder cancers.

Sep 11, 2013
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New method for early detection of colon cancer

A new, highly sensitive method to detect genetic variations that initiate colon cancer could be readily used for noninvasive colon cancer screening, according to a study published in Cancer Prevention Research, a journal of the ...

Sep 04, 2013
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Need for national Canadian strategy for EGFR testing

Significant advances have taken place in the management of patients with advanced and metastatic non–small-cell lung cancer (NSCLC) over the last 5 years. Traditionally, all advanced NSCLC patients were treated in a similar ...

Jul 25, 2013
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Polymerase

A polymerase (EC 2.7.7.6/7/19/48/49) is an enzyme whose central function is associated with polymers of nucleic acids such as RNA and DNA. The primary function of a polymerase is the polymerization of new DNA or RNA against an existing DNA or RNA template in the processes of replication and transcription. In association with a cluster of other enzymes and proteins, they take nucleotides from solvent, and catalyse the synthesis of a polynucleotide sequence against a nucleotide template strand using base-pairing interactions.

It is an accident of history that the enzymes responsible for the catalytic production of other biopolymers are not also referred to as polymerases.

One particular polymerase, from the thermophilic bacterium, Thermus aquaticus (Taq) (PDB 1BGX, EC 2.7.7.7) is of vital commercial importance due to its use in the polymerase chain reaction, a widely used technique of molecular biology.

Other well-known polymerases include:

This text uses material from Wikipedia licensed under CC BY-SA