News tagged with potent inhibitors
Preclinical study indicates potential for novel inhibitor to overcome drug resistance induced by RAF, MEK inhibitors
A new class of investigational medicines may help to treat patients with cancers driven by mutations in genes such as BRAF or KRAS/NRAS, including those patients who have become resistant to therapies that target BRAF directly, ...
Cancer
Apr 08, 2013 |
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Malaria drug treatment breakthrough
An international study, involving researchers from Griffith University's Eskitis Institute, has discovered a molecule which could form the basis of powerful new anti-malaria drugs.
Medications
Mar 22, 2013 |
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Elusive substrate protein identified in the most common form of heritable rickets
(Medical Xpress)—Diagnosed in toddlers, X-linked hypophosphatemia (XLH) is the most common form of heritable rickets, in which soft bones bend and deform, and tooth abscesses develop because infections penetrate soft teeth ...
Medical research
Feb 20, 2013 |
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New compound overcomes drug-resistant Staph infection in mice
Researchers have discovered a new compound that restores the health of mice infected with methicillin-resistant Staphylococcus aureus (MRSA), an otherwise dangerous bacterial infection. The new compound targets ...
Medical research
Jan 07, 2013 |
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Pharmacy researcher finds most popular weight-loss drug strongly alters other drug therapies
A University of Rhode Island researcher has discovered that the weight-loss drug orlistat, known by the brand names Xenical and Alli, inhibits a key enzyme that may lead to "severe toxicity of internal organs such as the ...
Medications
Dec 10, 2012 |
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New mechanism of action for PARP inhibitors discovered
New understanding of how drugs called PARP inhibitors, which have already shown promise for the treatment of women with familial breast and ovarian cancers linked to BRCA mutations, exert their anticancer effects has led ...
Cancer
Nov 09, 2012 |
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Research identifies new therapeutic target for Alzheimer's disease
Research led by Chu Chen, PhD, Associate Professor of Neuroscience at LSU Health Sciences Center New Orleans, has identified an enzyme called Monoacylglycerol lipase (MAGL) as a new therapeutic target to treat or prevent ...
Alzheimer's disease & dementia
Nov 01, 2012 |
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Study shows potential of anti-growth factor drugs for reducing complication of advanced ovarian cancer
Blocking the action of vascular endothelial growth factor (VEGF) with the new anti-VEGF drug aflibercept can curb the development of malignant ascites (excessive fluid in the abdomen), a common and painful complication of ...
Cancer
Dec 20, 2011 |
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Small molecules can starve cancer cells
All cells in our body have a system that can handle cellular waste and release building blocks for recycling. The underlying mechanism is called autophagy and literally means "self-eating". Many cancer cells have increased ...
Cancer
Oct 09, 2011 |
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