Amplification of a Stat5 gene produces excess oncogenic protein that drives prostate cancer spread
An international group of investigators, led by researchers at Thomas Jefferson University's Kimmel Cancer Center, have solved the mystery of why a substantial percentage of castrate-resistant metastatic prostate cancer cells ...
Cancer
May 07, 2013 |
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Study confirms everolimus can overcome trastuzumab resistance in HER-2 positive early breast cancer
A study that aimed to understand how the cancer drug everolimus helps overcome the resistance breast cancers can develop to trastuzumab has left researchers contemplating a puzzle.
Cancer
May 02, 2013 |
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Researchers find potential novel treatment for influenza
An experimental drug has shown promise in treating influenza, preventing lung injury and death from the virus in preclinical studies, according to University of Maryland School of Medicine researchers publishing in the journal ...
Diseases, Conditions, Syndromes
May 01, 2013 |
4.3 / 5 (3) |
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Promising new antibiotic targets potentially deadly gut infections
(Medical Xpress)—Researchers at the University of Virginia School of Medicine have developed a promising new antibiotic to treat potentially deadly gastrointestinal infections without harming the beneficial probiotic bacteria ...
Diseases, Conditions, Syndromes
Apr 12, 2013 |
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AKT inhibitor AZD5363 well tolerated, yielded partial response in patients with advanced solid tumors
The investigational drug AZD5363, which has shown activity in preclinical studies, was well tolerated in humans, and two patients with advanced solid tumors showed partial response, according to data presented at the AACR ...
Cancer
Apr 08, 2013 |
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Local chemotherapy has a stronger effect on reducing tumor growth
Reducing the growth of a tumor by localized delivery of cancer medication can be achieved by using a combination of ultrasound, temperature-sensitive nanoparticles and MRI. This is shown by Mariska de Smet ...
Cancer
Mar 14, 2013 |
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Sildenafil for heart failure does not result in significant improvement in exercise capacity
Among patients with heart failure with preserved ejection fraction (a measure of heart function), administration of sildenafil (commercially known as Viagra) for 24 weeks, compared with placebo, did not result in significant ...
Cardiology
Mar 11, 2013 |
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NIH clinical trial begins for treatment of rare, fatal neurological disorder
A clinical trial to evaluate a drug candidate called cyclodextrin as a possible treatment for Niemann-Pick disease type C1 (NPC), a rare and fatal genetic disease, will start today, researchers announced. Scientists from ...
Diseases, Conditions, Syndromes
Jan 23, 2013 |
5 / 5 (1) |
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Study: 'ApoE is an ideal target for halting progression of Alzheimer's disease'
Despite researchers' best efforts, no drug exists that can slow, halt or reverse the onslaught of Alzheimer's disease. A progressive and fatal neurodegenerative disorder, Alzheimer's has stolen the memories and livelihoods ...
Alzheimer's disease & dementia
Dec 05, 2012 |
5 / 5 (1) |
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Clinical trial targets advanced prostate cancer
Select patients with advanced prostate cancer may benefit from a Georgia Health Sciences University Cancer Center clinical trial that looks to improve survival rates of the FDA-approved prostate cancer drug Provenge.
Cancer
Dec 03, 2012 |
5 / 5 (1) |
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Mechanisms of action for green tea extract in breast cancer prevention identified
An oral green tea extract, Polyphenon E, appears to inhibit vascular endothelial growth factor and hepatocyte growth factor, both of which promote tumor cell growth, migration and invasion.
Cancer
Oct 18, 2012 |
5 / 5 (1) |
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Workshop calls for more detailed reporting in animal studies
A workshop sponsored by NIH's National Institute of Neurological Disorders and Stroke (NINDS) has produced a set of consensus recommendations to improve the design and reporting of animal studies. By making animal studies ...
Other
Oct 10, 2012 |
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CU Cancer Center opens phase I clinical trial of anti-cancer stem cell agent OMP-54F28
The University of Colorado Cancer Center, together with other participating academic medical centers, recently opened a phase I human clinical trial of the drug OMP-54F28 in patients with advanced solid tumor cancers. OMP-54F28, ...
Cancer
Oct 03, 2012 |
5 / 5 (2) |
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New hope for taming triple-negative breast cancer
Disease-free survival is short-lived for women with triple-negative breast cancer—a form of the disease that doesn't respond to hormone drugs and becomes resistant to chemotherapy. Thankfully, a promising ...
Cancer
Oct 02, 2012 |
5 / 5 (2) |
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Camptothecin analog FL118 shown to inhibit production of key cancer survival genes
(Medical Xpress)—Some 500,000 people die of cancer in the United States each year, often because their cancers have become resistant to approved therapies. Scientists at Roswell Park Cancer Institute (RPCI) have made headway ...
Cancer
Sep 21, 2012 |
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