Immunology
Cell research on rare disease finds new link to inflammation
"How many people actually have this disease?"
Feb 28, 2022
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71
News tagged with proteasome
Oncology & Cancer
Identification of a novel therapeutic target in multiple myeloma
Multiple myeloma is a cancer of the bone marrow, with a life expectancy of less than 5 years post-diagnosis. Proteasome inhibitors, the therapeutic backbone of current treatments, are very effective in treating newly diagnosed ...
Jan 12, 2022
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18
Oncology & Cancer
Researchers discover that proteasome molecules can join forces to prevent cancer
Managing the waste that cells produce is an essential function of the human body, as any defect in its elimination mechanisms can lead to cancer and neurodegenerative diseases. Now a Canadian study sheds light on a new mechanism ...
Nov 30, 2021
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68
Medications
Venetoclax shown to benefit patients with Waldenström Macroglobulinemia, including some who relapsed
A drug that strips cancer cells of their quest for immortality represents an effective new option for patients with Waldenström macroglobulinemia, including those not helped by the only class of drugs currently approved ...
Nov 19, 2021
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3
Medical research
Study shows how loss of de-N-glycosylation enzyme causes ill effect
Cytosolic peptide:N-glycanase (NGLY1) is a widely conserved enzyme involved in de–N-glycosylation of N-glycosylated proteins. Mutations in the human NGLY1 gene cause global developmental delay and multisystemic symptoms, ...
Jul 6, 2021
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5
Neuroscience
Why do structural differences in α-synuclein aggregates cause different pathologies?
Misfolding and aggregation of normally soluble proteins are common pathological features of many neurodegenerative diseases, including Alzheimer's, Parkinson's, Creutzfeldt-Jacob and Huntington's diseases. For example, Parkinson's ...
Sep 29, 2020
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5
Medical research
Erectile dysfunction drugs can help cells destroy misfolded proteins
The aberrant buildup of misfolded proteins is a hallmark of a host of disorders, including neurodegenerative diseases such as Alzheimer's and Parkinson's. Aggregates of these toxic proteins wreak havoc on the function of ...
Jul 22, 2020
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498
Medical research
Ability to eliminate spent proteins influences brain aging and individual life span
Aging is the main risk factor for dementia and Parkinson's disease. As age progresses, toxic protein aggregates pile up in the brain and impair neuronal function. But why does that happen? An international team of scientists ...
Jun 19, 2020
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116
Medical research
Tracking down 'illegal parkers' in cancer cells
Squamous cell carcinoma is a very unusual type of cancer. It occurs in many tissues—for example in the lungs, esophagus, pancreas, throat and pharynx, and on the skin. Due to the many mutations in this type of cancer, treatment ...
Mar 10, 2020
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2
Neuroscience
Neurodegenerative diseases may be caused by transportation failures inside neurons
All neurodegenerative diseases have a common thread: the appearance of protein clumps in the brain such as amyloid-beta plaques in Alzheimer's disease and alpha synuclein aggregates in Parkinson's. The root cause of this ...
Dec 3, 2019
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