The typical job of the proteasome, the garbage disposal of the cell, is to grind down proteins into smaller bits and recycle some of those bits and parts. That's still the case, for the most part, but, Johns Hopkins Medicine ...
Apr 12, 2024
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67
The waste system of living cells, the proteasome, not only shreds disused or damaged proteins, it also supports the immune system by recognizing virally infected or cancerous cells by producing protein fragments, so-called ...
Feb 14, 2024
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55
Structural insights into a potent antimalarial drug candidate's interaction with the malaria parasite Plasmodium falciparum have paved the way for drug-resistant malaria therapies, according to a new study by researchers ...
Jan 18, 2024
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7
Smart users of social media protect themselves by deleting suspicious "friend requests" that might serve as a gateway to harmful content. Similarly, our immune system uses its own judgment to identify cellular "profiles" ...
Sep 20, 2023
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26
Cold activates a cellular cleansing mechanism that breaks down harmful protein aggregations responsible for various diseases associated with aging. In recent years, studies on different model organisms have already shown ...
Apr 3, 2023
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344
"How many people actually have this disease?"
Feb 28, 2022
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71
Managing the waste that cells produce is an essential function of the human body, as any defect in its elimination mechanisms can lead to cancer and neurodegenerative diseases. Now a Canadian study sheds light on a new mechanism ...
Nov 30, 2021
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68
The aberrant buildup of misfolded proteins is a hallmark of a host of disorders, including neurodegenerative diseases such as Alzheimer's and Parkinson's. Aggregates of these toxic proteins wreak havoc on the function of ...
Jul 22, 2020
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498
All neurodegenerative diseases have a common thread: the appearance of protein clumps in the brain such as amyloid-beta plaques in Alzheimer's disease and alpha synuclein aggregates in Parkinson's. The root cause of this ...
Dec 3, 2019
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404
The cells of most patients' cancers are resistant to a class of drugs, called proteasome inhibitors, that should kill them. When studied in the lab, these drugs are highly effective, yet hundreds of clinical trials testing ...
May 28, 2019
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