A novel system to control protein aggregation in a model of Parkinson's disease may answer longstanding questions about how the disease begins and spreads, according to a new study published March 9 in the open-access journal ...
Mar 22, 2022
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Huntington's, Alzheimer's, ALS, and multiple other neurodegenerative diseases share a commonality: They are all characterized by proteins (different ones for each disease) aggregating in neurons within the brain and nervous ...
Feb 16, 2022
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Alexander disease is a progressive and rare neurological disorder with no cure or standard course of treatment. But a new study led by researchers at the University of Wisconsin–Madison involving a rat model of the disease ...
Nov 17, 2021
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Stephen Hawking, the world-famous theoretical physicist, was diagnosed with amyotrophic lateral sclerosis (ALS) at the age of 21. ALS is a rare motor neuron disease that usually affects individuals over the age of 60. Hawking ...
Aug 13, 2021
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Cancer has been recently shown to be affected by protein clusters, particularly by the aggregation of mutant variants of the tumor suppressor protein p53, which are present in more than half of malignant tumors. However, ...
May 4, 2021
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Scientists are still a long way from being able to treat Alzheimer's Disease, in part because the protein aggregates that can become brain plaques, a hallmark of the disease, are hard to study. The plaques are caused by the ...
Feb 26, 2021
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The older we grow, the weaker our muscles get, riddling old age with frailty and physical disability. But this doesn't only affect the individual, it also creates a significant burden on public healthcare. And yet, research ...
Jan 19, 2021
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425
Alzheimer's disease develops over decades. It begins with a fatal chain reaction in which masses of misfolded beta-amyloid proteins are produced that in the end literally flood the brain. Researchers including Mathias Jucker ...
Nov 17, 2020
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In many neurodegenerative diseases like Parkinson's, protein aggregates form in the brain and are assumed to contribute to neuronal cell death. Yet there exists a cellular defense mechanism that counteracts these aggregates, ...
Nov 11, 2020
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73
Alzheimer's disease is the leading cause of dementia worldwide and a major cause of disability. Now, researchers at Osaka University and Hokkaido University have shown that repeated precipitation-dissolution events of salt ...
Jul 27, 2020
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