Physicians have used the drug metformin to treat type 2 diabetes for more than half a century, but despite its prevalence, researchers have lacked a clear understanding of how it works. Now, Yale researchers have elucidated ...
Mar 3, 2022
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Adenoviruses have a linchpin protein that stabilizes their DNA until it reaches the infected cell's nucleus. The protein then detaches from the viral genome, and the virus uncoats. Only then are the genes released into the ...
Dec 21, 2021
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Scientists at Scripps Research, Florida have determined the near-atomic-scale structure of an unusual brain-cell receptor called GPR158, which has been linked to depression and anxiety.
Nov 18, 2021
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Within the brain and other parts of the nervous system, synapses are key junctional points in between neurons (the nerve cells) where critical signals are transmitted. More specifically, the "glutamatergic" synapses are the ...
Oct 6, 2021
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Researchers at UC San Francisco and UC San Diego have mapped out how hundreds of mutations involved in two types of cancer affect the activity of proteins that are the ultimate actors behind the disease. The work points the ...
Sep 30, 2021
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The Cedars-Sinai investigators discovered several key components in the control of telomerase reverse transcriptase, or TERT, expression, one of the necessary component proteins of telomerase. High levels of TERT are found ...
Sep 15, 2021
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St. Jude Children's Research Hospital immunologists have identified how immune sensors in infected cells organize and launch a multi-faceted innate immune response to infections with live viruses and bacteria. The discovery ...
Sep 1, 2021
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A research team led by Wim Annaert (VIB-KU Leuven) uncovered the early assembly of gamma-secretase, a protein complex linked to numerous cellular processes including the development of Alzheimer's disease. In a first step, ...
Jul 22, 2021
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Affecting over 50 million people, Alzheimer's disease is the most common form of dementia and primarily occurs in people over the age of 65. The pathology of the disease in the brain is mainly characterized by two factors: ...
Jun 11, 2021
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In a new study, researchers from Osaka University discovered a novel molecular mechanism by which immune cells migrate to fight off infections. These findings may help in understanding the development of certain immune deficiency ...
Jun 7, 2021
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