News tagged with protein degradation

Targeting cancer proteins for degradation

Cancer research is increasingly focusing on therapeutic approaches in which disease causing proteins are marked for early degradation. Nicolas Thomä and his group at the Friedrich Miescher Institute for Biomedical Research ...

Feb 24, 2016
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Slowing down muscle loss in heart failure patients

Patients in advanced states of myocardial insufficiency generally lose their muscle mass and muscle strength. Indeed, that fact has, until now, negatively impacted the clinical course of the disease and has resulted in poor ...

Aug 11, 2015
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Insights into a rare genetic disease

Recently, a grassroots effort initiated by families and clinicians led to the discovery of a human genetic disorder with severe consequences that is linked to a mutation in the human NGLY1 gene. In a big step towards understanding ...

Jan 19, 2015
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Mechanism of action of thalidomide elucidated

(Medical Xpress)—Scientists led by Nicolas Thomä at the Friedrich Miescher Institute for Biomedical Research have clarified the workings of thalidomide at the molecular level. Their analysis of various structures, published ...

Jul 17, 2014
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