MECP2 duplication affects immune system as well as brain development
In 1999, Dr. Huda Zoghbi and colleagues at Baylor College of Medicine identified the genetic cause of Rett syndrome (a neurological disorder that begins after birth) – MECP2 mutation. Too little of the MeCP2 protein associated ...
Medical research
Dec 05, 2012 |
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Managing cellular security systems
Conventional dendritic cells (cDCs) are the immune system's patrol. They recognize foreign threats and trigger a defensive response, while restraining immune reactions against inappropriate targets like host ...
Medical research
Nov 30, 2012 |
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Enzyme inhibition protects against Huntington's disease damage in two animal models
Treatment with a novel agent that inhibits the activity of SIRT2, an enzyme that regulates many important cellular functions, reduced neurological damage, slowed the loss of motor function and extended survival in two animal ...
Neuroscience
Nov 29, 2012 |
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Tapping into calcium's role in a healthy heart
Australian scientists are getting closer to decoding the way molecules interact to enable regular heart function.
Cardiology
Nov 21, 2012 |
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Immune cell migration is impeded in Huntington's disease
Huntington disease (HD) is an incurable neurodegenerative disease caused by a mutation in the huntingtin gene (htt). Though most of the symptoms of HD are neurological, the mutant HTT protein is expressed in non-neural cells ...
Diseases, Conditions, Syndromes
Nov 19, 2012 |
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Pig tissue scaffolding allows hearts to be rebuilt post-implant
(Medical Xpress)—Using tissue from pigs, scientists at the Technion-Israel Institute of Technology have created a "scaffold" that preserves the infrastructure of natural blood vessels and supports human ...
Medical research
Nov 13, 2012 |
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Preclinical muscular dystrophy data shows promise
Cedars-Sinai Heart Institute researchers have found that an experimental compound may help stem the debilitating effects of muscular dystrophy by restoring normal blood flow to muscles affected by the genetic disorder.
Medical research
Nov 08, 2012 |
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Losing protein helps heart recover, scientists say
When a person has a heart attack, portions of the heart muscle die in the next several days or even weeks if deprived of oxygen for long enough. The recovering heart slowly remodels itself, even fostering the growth of new ...
Cardiology
Nov 06, 2012 |
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Scientists find Achilles' heel of cancer cells
Several substances inhibiting so-called HDAC enzymes have been studied in trials searching for new anti-cancer drugs in recent years. "Trials have shown that HDAC inhibitors are very effective in arresting growth of cultured ...
Cancer
Nov 05, 2012 |
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Single protein targeted as the root biological cause of several childhood psychiatric disorders
A new research discovery has the potential to revolutionize the biological understanding of some childhood psychiatric disorders. Specifically, scientists have found that when a single protein involved in brain development, ...
Medical research
Oct 31, 2012 |
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Unlocking the secrets of DNA repair
Scientists from the University of Sheffield have unlocked one of the secrets to DNA repair—helping doctors identify DNA base damage and a patient's susceptibility to certain types of cancer.
Cancer
Oct 31, 2012 |
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Study finds diabetes raises levels of proteins linked to Alzheimer's features
Growing evidence suggests that there may be a link between diabetes and Alzheimer's disease, but the physiological mechanisms by which diabetes impacts brain function and cognition are not fully understood. ...
Alzheimer's disease & dementia
Oct 26, 2012 |
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Researchers identify genetic cause of MMPSI, rare infant epileptic disorder
A Yale-led team of researchers has identified the gene that, when mutated, causes a devastating early-onset disorder in babies known as "malignant migrating partial seizures of infants," or MMPSI. The study ...
Genetics
Oct 24, 2012 |
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Calcium reveals connections between neurons
A team led by MIT neuroscientists has developed a way to monitor how brain cells coordinate with each other to control specific behaviors, such as initiating movement or detecting an odor.
Neuroscience
Oct 17, 2012 |
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Eating lots of carbs, sugar may raise risk of cognitive impairment, study finds
People 70 and older who eat food high in carbohydrates have nearly four times the risk of developing mild cognitive impairment, and the danger also rises with a diet heavy in sugar, Mayo Clinic researchers have found. Those ...
Alzheimer's disease & dementia
Oct 16, 2012 |
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