News tagged with protein kinase inhibitors
Discovery promises to improve drugs used to fight cancer, other diseases
(Medical Xpress)—Even when at rest, the human body is a flurry of activity. Like a microscopic metropolis locked in a state of perpetual rush hour traffic, the trillions of cells that make us who we are work feverishly ...
Medical research
Jan 11, 2013 |
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Novel test identifies patients most likely to benefit from ALK inhibition therapy
Approximately one in 20 patients with non-small cell lung carcinoma (NSCLC) has chromosomal aberrations targeting the anaplastic lymphoma kinase (ALK) gene. This has considerable implications for treatment because these patients ...
Medical research
Dec 12, 2012 |
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Clinical trial delivers good results in leukemia patients
Huntsman Cancer Institute (HCI) researchers Michael Deininger, M.D., Ph.D., and Thomas O'Hare, Ph.D., were part of a team that found a potent oral drug, ponatinib, effective in patients who have developed resistance to standard ...
Cancer
Nov 30, 2012 |
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Popular antidepressant might prevent heart failure
A medication usually used to help treat depression and anxiety disorders has the potential to help prevent heart failure, according to researchers at the University of Michigan.
Medications
Oct 01, 2012 |
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Making it easier to make stem cells
The process researchers use to generate induced pluripotent stem cells (iPSCs)—a special type of stem cell that can be made in the lab from any type of adult cell—is time consuming and inefficient. To ...
Medical research
Sep 25, 2012 |
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Vandetanib almost doubles progression free survival in patients with thyroid cancer
Results of a phase 2 randomised trial for patients with advanced differentiated thyroid cancer (DTC) show that those treated with the oral targeted agent vandetanib survived without the disease getting worse for almost twice ...
Cancer
Aug 13, 2012 |
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Jak of all trades? Not of leukaemia therapy
About one in five or six cases of adult leukaemia in Western populations relates to so-called chronic myeloid leukaemia, or CML. Treatment of CML usually relies on inhibitors of the abnormal protein that causes the condition ...
Cancer
Jan 30, 2012 |
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Combination therapies for drug-resistant cancers
Some cancers can be effectively treated with drugs inhibiting proteins known as receptor tyrosine kinases, but not those cancers caused by mutations in the KRAS gene. A team of researchers led by Jeffrey Engelman, at Massachusetts ...
Cancer
Oct 10, 2011 |
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Cause and potential treatment found for cancer drug's kidney toxicity
Scientists may have a way to make the powerful cancer drug cisplatin less toxic to the kidneys and more effective against some cancers.
Cancer
Jun 02, 2011 |
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