Popular antidepressant might prevent heart failure
A medication usually used to help treat depression and anxiety disorders has the potential to help prevent heart failure, according to researchers at the University of Michigan.
Medications
Oct 01, 2012 |
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Making it easier to make stem cells
The process researchers use to generate induced pluripotent stem cells (iPSCs)—a special type of stem cell that can be made in the lab from any type of adult cell—is time consuming and inefficient. To ...
Medical research
Sep 25, 2012 |
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Study: Common gene mutation affects kids with autism spectrum disorders
(Medical Xpress)—Over the past decade, researchers have made great strides in identifying genes that lead to an increased risk of autism spectrum disorders (ASD), which result in a continuum of social deficits, communication ...
Autism spectrum disorders
Sep 14, 2012 |
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Charting the SH2 pool
New research published in BioMed Central's open access journal Cell Communication and Signaling describes a large set of interactions (interactome) which maps the range of phosphotyrosine (pTyr)-dependent interactions with S ...
Medical research
Sep 13, 2012 |
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Mathematical modelling to tackle metabolic diseases
Predictive mathematical models of signalling pathways are powerful biological tools that could be used for drug development. Using a similar approach, European scientists developed a computational model for ...
Medical research
Aug 30, 2012 |
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Metabolic protein wields phosphate group to activate cancer-promoting genes
A metabolic protein that nourishes cancer cells also activates tumor-promoting genes by loosening part of the packaging that entwines DNA to make up chromosomes, a team led by scientists at The University of Texas MD Anderson ...
Cancer
Aug 16, 2012 |
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Vandetanib almost doubles progression free survival in patients with thyroid cancer
Results of a phase 2 randomised trial for patients with advanced differentiated thyroid cancer (DTC) show that those treated with the oral targeted agent vandetanib survived without the disease getting worse for almost twice ...
Cancer
Aug 13, 2012 |
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Discovery explains how cellular pathways converge to regulate food intake and body weight
In the complex chain of molecular events that underlie eating behaviors and body weight, the AMP-activated protein kinase (AMPK) enzyme has proven to be a critical link.
Medical research
Jul 03, 2012 |
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When being scared twice is enough to remember
One of the brain's jobs is to help us figure out what's important enough to be remembered. Scientists at Yerkes National Primate Research Center, Emory University have achieved some insight into how fleeting experiences become ...
Neuroscience
Jun 12, 2012 |
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Fighting cancer with the immune system
The human immune system has a natural ability to identify and attack tumor cells. Natural killer (NK) cells are innate immune cells that are particularly effective at killing tumor cells due to their ability to secrete cytotoxic ...
Cancer
Jun 11, 2012 |
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ASCO: Trametinib improves survival in metastatic melanoma
(HealthDay) -- For patients with metastatic melanoma with activating mutations in serine-threonine protein kinase B-RAF (BRAF), treatment with the oral selective MEK inhibitor trametinib is associated with ...
Cancer
Jun 05, 2012 |
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Researchers identify drivers of sarcoma growth and survival
To better understand the signaling pathways active in sarcomas, researchers at Moffitt Cancer Center used state-of-the-art mass spectrometry-based proteomics to characterize a family of protein enzymes that act as "on" or ...
Cancer
May 02, 2012 |
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Scientists identify important mechanism that affects the aging process
Scientists at Joslin Diabetes Center have identified a key mechanism of action for the TOR (target of rapamycin) protein kinase, a critical regulator of cell growth which plays a major role in illness and aging. This finding ...
Medical research
May 01, 2012 |
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Researchers find potential for new uses of old drug
(Phys.org) -- Researchers in Canada, Scotland and Australia have discovered that salicylate, the active ingredient in aspirin, directly increases the activity of the protein AMPK (AMP-activated protein kinase), a key player ...
Medications
Apr 19, 2012 |
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Metal binding important for metformin action
(HealthDay) -- The ability of metformin to bind mitochondrial copper may be essential to its mechanism of action, according to a study published online April 9 in Diabetes.
Diabetes
Apr 14, 2012 |
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