News tagged with protein kinase

Hedgehog pathway key in tamoxifen-resistant breast CA

(HealthDay)—Noncanonical Hedgehog (Hh) signaling is activated in tamoxifen-resistant tumors, and the phosphoinositide 3-kinase inhibitor/protein kinase B (PI3K/AKT) pathway plays a key role protecting Hh ...

Nov 06, 2012
popularity not rated yet | comments 0

Making it easier to make stem cells

The process researchers use to generate induced pluripotent stem cells (iPSCs)—a special type of stem cell that can be made in the lab from any type of adult cell—is time consuming and inefficient. To ...

Sep 25, 2012
popularity 5 / 5 (3) | comments 2 | with audio podcast

Charting the SH2 pool

New research published in BioMed Central's open access journal Cell Communication and Signaling describes a large set of interactions (interactome) which maps the range of phosphotyrosine (pTyr)-dependent interactions with S ...

Sep 13, 2012
popularity not rated yet | comments 0

When being scared twice is enough to remember

One of the brain's jobs is to help us figure out what's important enough to be remembered. Scientists at Yerkes National Primate Research Center, Emory University have achieved some insight into how fleeting experiences become ...

Jun 12, 2012
popularity 5 / 5 (1) | comments 0 | with audio podcast

Fighting cancer with the immune system

The human immune system has a natural ability to identify and attack tumor cells. Natural killer (NK) cells are innate immune cells that are particularly effective at killing tumor cells due to their ability to secrete cytotoxic ...

Jun 11, 2012
popularity not rated yet | comments 0

Researchers identify drivers of sarcoma growth and survival

To better understand the signaling pathways active in sarcomas, researchers at Moffitt Cancer Center used state-of-the-art mass spectrometry-based proteomics to characterize a family of protein enzymes that act as "on" or ...

May 02, 2012
popularity not rated yet | comments 0

Researchers find potential for new uses of old drug

(Phys.org) -- Researchers in Canada, Scotland and Australia have discovered that salicylate, the active ingredient in aspirin, directly increases the activity of the protein AMPK (AMP-activated protein kinase), a key player ...

Apr 19, 2012
popularity not rated yet | comments 0 | with audio podcast