Lack of iron regulating protein contributes to high blood pressure of the lungs
A protein known to regulate iron levels in the body has an unexpectedly important role in preventing a form of high blood pressure that affects the lungs, and in stabilizing the concentration of red cells ...
Medical research
Feb 14, 2013 |
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Study identifies liver gene that regulates cholesterol and fat blood levels
Researchers have identified a microRNA liver gene, miR-27b, which regulates lipid (cholesterol or fat) levels in the blood. This regulator gene controls multiple genes involved in dyslipidemia—abnormal blood cholesterol ...
Genetics
Feb 07, 2013 |
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New model may help predict response to chemotherapy for colorectal cancer
Scientists may be able to better predict which patients with colorectal cancer will respond to chemotherapy using a new mathematical model that measures the amount of stress required for a cancer cell to die without harming ...
Cancer
Jan 17, 2013 |
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Study deflates notion that pear-shaped bodies more healthy than apples
People who are "apple-shaped"—with fat more concentrated around the abdomen—have long been considered more at risk for conditions such as heart disease and diabetes than those who are "pear-shaped" and ...
Health
Jan 10, 2013 |
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Small peptide ameliorates autoimmune skin blistering disease in mice
Pemphigus vulgaris is a life-threatening autoimmune skin disease that is occurs when the body's immune system generates antibodies that target proteins in the skin known as desomogleins. Desmogleins help to form the adhesive ...
Immunology
Jan 09, 2013 |
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Cellular fuel gauge may hold the key to restricting cancer growth
Researchers at McGill University have discovered that a key regulator of energy metabolism in cancer cells known as the AMP-activated protein kinase (AMPK) may play a crucial role in restricting cancer cell growth. AMPK acts ...
Cancer
Dec 27, 2012 |
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Blood levels of immune protein predict risk in Hodgkin disease
Blood levels of an immunity-related protein, galectin-1, in patients with newly diagnosed Hodgkin lymphoma reflected the extent of their cancer and correlated with other predictors of outcome, scientists reported at the American ...
Cancer
Dec 10, 2012 |
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(Antibody) orientation matters
The orientation of antibody binding to bacteria can mean life or death to the bug, according to a study published in The Journal of Experimental Medicine on December 10th. These findings may help explain why these bacter ...
Medical research
Dec 10, 2012 |
4 / 5 (1) |
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Combination therapy using JAK2 and HSP90 inhibitors increased efficacy in myelofibrosis in vivo
Researchers have demonstrated that combination therapy with PU-H71 and ruxolitinib increases the durability and effectiveness of a treatment that had previously shown limited utility for patients with myelofibrosis.
Cancer
Dec 09, 2012 |
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New understanding can lead to srategies for dealing with neurodegenerative diseases
A new understanding of what takes place on the cellular level during the development of neurodegenerative diseases, such as Parkinson's, Alzheimer's, ALS and Huntington's diseases, offers promise towards ...
Medical research
Dec 06, 2012 |
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Scientists create roadmap to metabolic reprogramming for aging
In efforts to understand what influences life span, cancer and aging, scientists are building roadmaps to navigate and learn about cells at the molecular level.
Medical research
Nov 29, 2012 |
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Inflammation marker linked to increased risk for death from cancer in Korean men
Measuring blood levels of high-sensitive C-reactive protein, an important marker of inflammation, in apparently cancer-free men could potentially help identify those at increased risk for death from cancer, in particular ...
Cancer
Nov 07, 2012 |
5 / 5 (1) |
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Hedgehog pathway key in tamoxifen-resistant breast CA
(HealthDay)—Noncanonical Hedgehog (Hh) signaling is activated in tamoxifen-resistant tumors, and the phosphoinositide 3-kinase inhibitor/protein kinase B (PI3K/AKT) pathway plays a key role protecting Hh ...
Cancer
Nov 06, 2012 |
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Duke research team identifies a potent growth factor for blood stem cells
Duke Medicine researchers studying the interaction of blood stem cells and the niche where they reside have identified a protein that may be a long-sought growth factor for blood stem cells.
Medical research
Oct 23, 2012 |
5 / 5 (1) |
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Length matters in gene expression
A research team at Aarhus University reveals a surprising interplay between the ends of human genes: If a protein-coding gene is too short it becomes inactive! The findings also explain how some short genes have adapted to ...
Genetics
Oct 02, 2012 |
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