Diseases, Conditions, Syndromes

Researchers identify a new mechanism of TB drug resistance

Pyrazinamide (PZA)—a frontline tuberculosis (TB) drug—kills dormant persister bacteria and plays a critical role in shortening TB therapy. PZA is used for treating both drug susceptible and multi-drug resistant TB (MDR-TB) ...

Diseases, Conditions, Syndromes

Scientists: Novel TB drug combo passes first test

Scientists are hot on the trail of a new tuberculosis treatment that a small study suggests might one day offer an alternative to battle this deadly lung disease, even if it is resistant to today's two main drugs.

Medical research

Scientists explain unique activity of TB drug pyrazinamide

Pyrazinamide has been used in combination with other drugs as a first-line treatment for people with tuberculosis (TB) since the 1950s, but exactly how the drug works has not been well understood.