Medications

New drug target to treat pain from visceral organs

An approved drug for chronic constipation also relieves the pain associated with that condition. New research by Scott Waldman, MD, Ph.D., chair of pharmacology, physiology and cancer biology at Jefferson, demonstrates that ...

Neuroscience

Surprising culprit worsens stroke, TBI damage

In the aftermath of a stroke or TBI, a group of amino acids that typically support brain function contribute significantly to the brain destruction that can follow both these injuries, scientists report.

Immunology

Cells are able to 'talk to themselves' for better immune response

Research from the laboratories of Dr. André Veillette, Director of Research in Molecular Oncology at the Montreal Clinical Research Institute (IRCM) and Professor and Researcher in the Department of Medicine at the Université ...

Oncology & Cancer

Boosting the immune response against cancer

T cells are usually good at eliminating diseased cells, but they seem to fail when it comes to tumor cells. In JCI Insight, MDC teams led by Armin Rehm and Uta Höpken describe what inhibits this immune function, and how ...

Immunology

Double-stranded RNA induces bone loss during gum disease

Tokyo University of Agriculture and Technology researchers reported on a new discovery regarding the mechanisms for bone loss in gum disease (periodontitis). They found that double stranded RNA molecules can activate the ...

Diseases, Conditions, Syndromes

Evaluating an old molecule to fight SARS-CoV-2

In the spring of 2020, Université de Montréal biochemistry professor Christian Baron had an idea: Why not evaluate the inhibition capacity of a commercially available molecule called VE607 on the virus causing COVID-19?

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