Medical research

Excess dietary salt identified as autoimmune trigger

For the past few decades, health officials have been reporting increases in the incidence of autoimmune diseases such as multiple sclerosis (MS). Now researchers at Yale School of Medicine, Harvard Medical School and the ...

Medical research

Engineered T cells for type 1 diabetes move closer to clinic

For much of the last decade, Dr. David Rawlings, director of Seattle Children's Research Institute's Center for Immunity and Immunotherapies, has dreamed of developing a therapy for children with type 1 diabetes that doesn't ...

Oncology & Cancer

How immune cells in the tumor microenvironment make things worse

Cells from the immune system called CD4+ regulatory T cells, or simply Treg, are linked to tumor prognosis: the more Treg cells present in a tumor, the worst the prognosis. We know from previous research studies that Treg ...

Oncology & Cancer

Cancer immunotherapy 'uniquely suppressed' by liver tumors

Though cancer immunotherapy has become a promising standard-of-care treatment—and in some cases, perhaps a cure—for a wide variety of different cancers, it doesn't work for everyone, and researchers have increasingly ...

Immunology

Keeping a lid on inflammation

Regulatory T cells (Treg cells) are part of the system of checks and balances that prevents the immune response from going overboard and causing autoimmune disease. Although critically important for shaping the immune response ...

Immunology

An unexpected origin for calming immune cells in the gut

Biologically speaking, we carry the outside world within us. The food we ingest each day and the trillions of microbes that inhabit our guts pose a constant risk of infection—and all that separates us from these foreign ...

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