In clinical practice, drug resistance poses a significant challenge in cancer treatment. The process of developing resistance is regulated by complex decision-making pathways and genetic signal networks. The cross-redundancy ...
Dec 5, 2023
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Researchers led by the University of Tsukuba conducted a gene expression analysis at the single-cell level on pancreatic islets from prediabetic and diabetic mouse models. Their results are published in the journal Diabetes.
Nov 21, 2023
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Low levels of commonly used biocides, such as disinfectants and antiseptics, may increase antibiotic tolerance in Acinetobacter baumannii, a multi-drug resistant, hospital-acquired pathogen that causes serious wound, bloodstream ...
Oct 10, 2023
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Type 2 diabetes (T2D) is characterized by persistent hyperglycemia (high glucose in blood) that leads to hypoxia (low oxygen condition) in pancreatic β-cells.
Sep 20, 2023
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Antimicrobial resistance—the ability of microorganisms to resist drugs that have been developed to control them—is a severe problem in African countries. The continent has the highest global burden of antimicrobial-resistant ...
Sep 18, 2023
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Scientists from Queen Mary University of London have discovered two new genes that cause head and neck cancer patients to be resistant to chemotherapy, and that silencing either gene can make cancer cells previously unresponsive ...
Sep 4, 2023
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Mutations in the KRAS gene are the major driver of pancreatic cancer. The resulting protein controls multiple signaling pathways involved in cell growth and survival. In cancer, the gene is mutated to be permanently "on," ...
Jun 29, 2023
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Researchers at Washington University School of Medicine in St. Louis have identified a process in immune cells that links vitamin D deficiency during pregnancy to an increased risk of type 2 diabetes in offspring. The researchers ...
Jun 13, 2023
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Entry of the SARS-CoV-2 virus into human tissues depends on the activity of a host gene that regulates production of a key viral receptor, according to a study publishing June 13 in the open access journal PLOS Biology by ...
Jun 13, 2023
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A study of the DNA of more than 55,000 people worldwide has shed light on how we maintain healthy blood sugar levels after we have eaten, with implications for our understanding of how the process goes wrong in type 2 diabetes.
Jun 8, 2023
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