Study finds mutations linked to relapse of childhood leukemia
After an intensive three-year hunt through the genome, medical researchers have pinpointed mutations that leads to drug resistance and relapse in the most common type of childhood cancer—the first time anyone has linked ...
Genetics
Feb 03, 2013 |
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Medroxyprogesterone acetate linked to immune suppression
(HealthDay)—Use of the injectable contraceptive depot medroxyprogesterone acetate (MPA), common in areas such as sub-Saharan Africa with high HIV-1 prevalence, is associated with suppression of the immune ...
Immunology
Feb 01, 2013 |
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Tuberculosis may lurk in bone marrow stem cells of infected patients, researchers say
Tuberculosis is a devastating disease that kills nearly 2 million people worldwide each year. Although antibiotics exist that can ameliorate the symptoms, the courses of therapy last for months and don't completely eradicate ...
Medical research
Jan 30, 2013 |
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Synthetic corkscrew peptide kills antibiotic-resistant Gram-negative bacteria
An engineered peptide provides a new prototype for killing an entire category of resistant bacteria by shredding and dissolving their double-layered membranes, which are thought to protect those microbes from antibiotics.
Medical research
Jan 24, 2013 |
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Treatment targeting PI3K may delay resistance to anti-HER2 therapy in breast cancer patients
Patients with HER2-positive breast cancer being treated with anti-HER2 therapy may be able to prevent or delay resistance to the therapy with the addition of a phosphatidylinositol-3 kinase inhibitor to their treatment regimens.
Cancer
Jan 23, 2013 |
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Computational methods reveal how hospital-acquired bacteria spread
Scientists at the Academy of Finland's Centre of Excellence in Computational Inference Research have developed novel computational methods that have yielded essential knowledge of how hospital-acquired bacteria spread and ...
Diseases, Conditions, Syndromes
Jan 16, 2013 |
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Team finds gene that promotes drug resistance in cancer
Scientists from the University of Iowa and Brigham Young University (BYU) have identified a gene that may be a target for overcoming drug resistance in cancer. The finding could not only improve prognostic and diagnostic ...
Cancer
Jan 14, 2013 |
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Detrimental effect of obesity on lesions associated with Alzheimer's disease
Researchers from Inserm and the Université Lille/Université Lille Nord de France have recently used a neurodegeneration model of Alzheimer's disease to provide experimental evidence of the relationship between obesity and ...
Alzheimer's disease & dementia
Jan 07, 2013 |
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New compound overcomes drug-resistant Staph infection in mice
Researchers have discovered a new compound that restores the health of mice infected with methicillin-resistant Staphylococcus aureus (MRSA), an otherwise dangerous bacterial infection. The new compound targets ...
Medical research
Jan 07, 2013 |
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Clever gene construct combats metabolic syndrome
(Medical Xpress)—Researchers under ETH-Zurich professor Martin Fussenegger have created a new genetic network that could cure the various symptoms of so-called metabolic syndrome in one fell swoop. It already ...
Medical research
Dec 18, 2012 |
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Low adiponcetin associated with increased pancreatic cancer risk
Low prediagnostic levels of circulating adiponectin were associated with an increased risk of pancreatic cancer, according to a study published December 14 in the Journal of the National Cancer Institute.
Cancer
Dec 14, 2012 |
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New screening approach identified potential drug combos for difficult-to-treat melanomas
A novel approach to identifying potential anticancer drug combinations revealed that pairing cholesterol-reducing drugs called statins with cyclin-dependent kinase inhibitors might provide an effective approach to treating ...
Cancer
Dec 13, 2012 |
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To fight incurable metastatic breast cancer, resistance must be broken
One of the most frustrating truths about cancer is that even when a treatment works, it often doesn't work for long because cancer cells find ways to resist. However, researchers reporting studies done in mice in the December ...
Cancer
Dec 10, 2012 |
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Temple scientists target DNA repair to eradicate leukemia stem cells
Despite treatment with imatinib, a successful drug that targets chronic myeloid leukemia (CML), a deadly type of cancer, some patients may continue to be at risk for relapse because a tiny pool of stem cells is resistant ...
Cancer
Dec 09, 2012 |
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Mouse study offers clues to obesity-diabetes link
(HealthDay)—Obesity and type 2 diabetes are clearly intertwined, but researchers say they've found a way to weaken the connection between the two—at least in mice.
Medical research
Dec 06, 2012 |
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