News tagged with signal pathway
Same musicians: Brand new tune
A small ensemble of musicians can produce an infinite number of melodies, harmonies and rhythms. So too, do a handful of workhorse signaling pathways that interact to construct multiple structures that comprise ...
Medical research
May 14, 2013 |
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Brain-imaging study links cannabinoid receptors to post-traumatic stress disorder
In a first-of-its-kind effort to illuminate the biochemical impact of trauma, researchers at NYU Langone Medical Center have discovered a connection between the quantity of cannabinoid receptors in the human brain, known ...
Psychology & Psychiatry
May 14, 2013 |
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Researchers describe how breast cancer cells acquire drug resistance
A seven-year quest to understand how breast cancer cells resist treatment with the targeted therapy lapatinib has revealed a previously unknown molecular network that regulates cell death. The discovery provides new avenues ...
Cancer
May 07, 2013 |
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Scientists discover new target for personalized cancer therapy
A common cancer pathway causing tumor growth is now being targeted by a number of new cancer drugs and shows promising results. A team of researchers at Case Western Reserve University School of Medicine have developed a ...
Cancer
May 02, 2013 |
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Study confirms everolimus can overcome trastuzumab resistance in HER-2 positive early breast cancer
A study that aimed to understand how the cancer drug everolimus helps overcome the resistance breast cancers can develop to trastuzumab has left researchers contemplating a puzzle.
Cancer
May 02, 2013 |
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Workplace stress poses risk to health
Stressful situations at work can have a negative impact on the cardiovascular system and the metabolism. Stress, which is transmitted by direct and indirect signaling pathways, leads to an inflammatory response in the body, ...
Psychology & Psychiatry
Apr 23, 2013 |
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Blocking 'scaffold' protein inhibits cancer growth, study finds
(Medical Xpress)—Researchers at the Stanford University School of Medicine have devised an entirely novel way to block biological signaling pathways that, when overactive, lead to many types of cancers. They've done so ...
Cancer
Apr 22, 2013 |
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New drug combination therapy developed to treat leukemia
A new, pre-clinical study by researchers at Virginia Commonwealth University Massey Cancer Center suggests that a novel drug combination could lead to profound leukemia cell death by disrupting the function of two major pro-survival ...
Cancer
Apr 17, 2013 |
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Transcription factors regulating blood oxygen linked to melanoma metastases
Researchers at the University of North Carolina have discovered that transcription factors regulating the levels of oxygen in the blood also play a role in the spread of the skin cancer melanoma.
Cancer
Apr 16, 2013 |
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Soy-based compound may reduce tumor cell proliferation in colorectal cancer
Research on a soy-based treatment for colorectal cancer, a promising agent in ovarian cancer, and a new drug target for advanced prostate cancer was presented at the American Association for Cancer Research 2013 Annual Meeting. ...
Cancer
Apr 11, 2013 |
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Novel AKT pathway inhibitor, ARQ 092, demonstrated safety, effective target inhibition
Researchers have confirmed that the novel oral agent ARQ 092 inhibits the AKT pathway and has a manageable safety profile in patients with a variety of advanced solid tumors, according to phase I data presented at the AACR ...
Cancer
Apr 09, 2013 |
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AKT inhibitor AZD5363 well tolerated, yielded partial response in patients with advanced solid tumors
The investigational drug AZD5363, which has shown activity in preclinical studies, was well tolerated in humans, and two patients with advanced solid tumors showed partial response, according to data presented at the AACR ...
Cancer
Apr 08, 2013 |
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Feeling hungry may protect the brain against Alzheimer's disease, study finds
The feeling of hunger itself may protect against Alzheimer's disease, according to study published today in the journal PLOS ONE. Interestingly, the results of this study in mice suggest that mild hunger ...
Alzheimer's disease & dementia
Apr 03, 2013 |
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Breast cancer researchers find new drug target companion prognostic test for hormone therapy resistance
A team of international cancer researchers led by Dr. Mathieu Lupien at the Princess Margaret Cancer Centre, University Health Network, has identified the signalling pathway that is over-activated in estrogen receptor (ER)-positive ...
Cancer
Apr 01, 2013 |
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Scientists tie dietary influences to changes in gene expression and physiology
Sometimes you just can't resist a tiny piece of chocolate cake. Even the most health-conscious eaters find themselves indulging in junk foods from time to time. New research by scientists at the University of Massachusetts ...
Medical research
Mar 28, 2013 |
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