AI speeds up drug design for Parkinson's by ten-fold
Researchers have used artificial intelligence techniques to massively accelerate the search for Parkinson's disease treatments.
Apr 17, 2024
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Researchers have used artificial intelligence techniques to massively accelerate the search for Parkinson's disease treatments.
Apr 17, 2024
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In a new study published in Nature Biomedical Engineering, researchers at The University of Texas MD Anderson Cancer Center have designed a new method for developing immunotherapy drugs using engineered peptides to elicit ...
Apr 19, 2024
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New research being presented at the European Congress on Obesity (ECO) in Venice, Italy (12–15 May) identifies changes in the composition of gut bacteria that may play a key role in the onset and development of obesity, ...
Apr 2, 2024
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An international research team, led by Tibor Harkany and Robert Schnell at Karolinska Institutet and MedUni Vienna's Center for Brain Research, set out to find ways of influencing hormone release to reduce stress reactions ...
Apr 23, 2024
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Relapses in a common form of leukemia may be preventable following new research that has identified how the cancer develops resistance to first line treatments.
Apr 9, 2024
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Heart failure (HF) after myocardial infarction (MI) is a global health issue with a high mortality rate. Multiple molecular mechanisms are involved in the development of HF after MI. However, interventions targeting these ...
Apr 18, 2024
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Cardiovascular disease (CVD) refers to a group of disorders affecting the heart and blood vessels and is a leading cause of death globally. Lifestyle factors have been linked to the incidence of CVD and the inclusion of an ...
Mar 28, 2024
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Researchers have identified a protein that, when targeted, enables cisplatin-resistant cancer cells to become responsive to treatment. Cisplatin, and other similar platinum drugs, are incredibly effective at killing rapidly ...
Mar 27, 2024
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Scientists from the University of Aberdeen in collaboration with the University of Edinburgh and international partners, have identified a new way to detect signs of motor neuron disease (MND) in brain tissue that can pick ...
Mar 28, 2024
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In pharmacology and biochemistry, a small molecule is an organic compound that is not a polymer. Biopolymers such as nucleic acids, proteins, and polysaccharides (such as starch or cellulose) are not small molecules, although their constituent monomers—ribo- or deoxyribonucleotides, amino acids, and monosaccharides, respectively—are often considered to be. Very small oligomers are also usually considered small molecules, such as dinucleotides, peptides such as the antioxidant glutathione, and disaccharides such as sucrose.
While small molecules almost always have a lower molecular weight than biopolymers, a very small protein with a defined fold, such as the artificial ten-amino-acid protein chignolin[1], can indeed be smaller than some exceptionally large small molecules such as triglycerides.
Small molecules can have a variety of biological functions, serving as cell signalling molecules, as tools in molecular biology, as drugs in medicine, and in countless other roles. These compounds can be natural (such as secondary metabolites) or artificial (such as antiviral drugs); they may have a beneficial effect against a disease (such as FDA approved drugs) or may be detrimental (such as teratogens and carcinogens).
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